Abstract
We conducted this study to assess the efficacy of intermittent short course therapy in all forms of pediatric tuberculosis using a coordinated approach with Revised National Tuberculosis Control Programme (RNTCP). Sixty-five children were treated using RNTCP protocols with some modifications, such as dose adjustments or prolongation of treatment in selected children. Overall response rate was 95% (pulmonary 94% and extra pulmonary 97%). There was one case with possible relapse. With dynamic inputs from both the treating pediatrician and personnel from Directly Observed Treatment — Short-course (DOTS) centers, we could successfully implement RNTCP protocols in childhood tuberculosis.
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References
Chauhan LS, Arora VK. Management of pediatric tuberculosis under the Revised National Tuberculosis Control Program (RNTCP) — The consensus statement. Indian Pediatr 2004; 41: 901–905.
Kumar L, Dhand R, Singhi PD, Rao LN, Katariya S. A randomized trial of fully intermittent vs daily followed by intermittent short course chemotherapy for childhood tuberculosis. Pediatr Infect Dis J 1990; 19: 802–806.
Hong Kong Chest Service, British Medical Research Council. Controlled trial of four thriceweekly regimens and daily regimen all given for six months for pulmonary tuberculosis. Lancet 1981; 8213: 171–174.
Varudkar BL. Short-course chemotherapy for tuberculosis in children. Indian J Pediatr 1985; 52: 593–597.
Te Water Naude JM, Donald PR, Hussey GD, Kibel MA, Louw A, Perkins DR, et al. Twice weekly vs daily chemotherapy for childhood tuberculosis. Pediatr Infect Dis 2000; 19: 405–410.
Göçmen A, Ozçelic U, Kiper N, Toppare M, Kaya S, Cengizlier R, et al. Short course intermittent chemotherapy in childhood tuberculosis. Infection 1993; 21: 324–327.
Jawahar MS, Rajaram K, Sivasubramanian S, Paramasivan CN, Chandracekar K, Kamaludeen MN, et al. Treatment of lymph node tuberculosis- a randomized clinical trial of two 6-month regimens. Trop Med Int Health 2005; 10: 1090–1098.
Arora VK, Gupta R. Directly observed treatment for tuberculosis. Indian J Pediatr 2003; 70: 885–889.
Anadol D, Kiper N, Gocmen A, Ozcelik U. Intermittent chemotherapy for miliary tuberculosis in children. Turk J Pediatr 1999; 41: 53–59.
Rajeswari R, Sivasubramanian S, Balambal R, Parthasarathy R, Ranjar R, Santha T, et al. A controlled clinical trial of short-course chemotherapy for tuberculoma of the brain. Tuber Lung Dis 1995; 76: 311–317.
Venugopal K. Therapeutic efficacy of fully intermittent regimen for neuro TB-A field study in South India. Pulmon 2006; 8; 89–92.
Lodha R, Menon PR, Kabra SK. Concerns on the dosing of antitubercular drugs for children in RNTCP. Indian Pediatr 2008; 45: 852–854.
Kabra SK, Lodha R, Seth V. Category based treatment of tuberculosis in children. Indian Pediatr 2004; 41: 927–937.
Jacobs RF, Sunacorn P, Chotpttayasunonah TC, Pope S, Kelleher K. Intensive short course chemotherapy for tuberculous meningitis. Pediatr Infect Dis J 1992; 11: 194–198.
Van Loenhout-Rooyackers JH, Keyser A, Laheij JF, Varbeek ALM, Van der meer JWM. Tuberculous meningitis: is a 6-month treatment regimen sufficient? Int J Tuberc Lung Dis 2001; 5: 1028–1035.
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Indumathi, C.K., Kumar Prasanna, K., Dinakar, C. et al. Intermittent short course therapy for pediatric tuberculosis. Indian Pediatr 47, 93–96 (2010). https://doi.org/10.1007/s13312-010-0012-7
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DOI: https://doi.org/10.1007/s13312-010-0012-7