Hypoglossal Nerve Stimulation Therapy for the Treatment of Obstructive Sleep Apnea

Abstract

Hypoglossal nerve stimulation (HGNS) therapy was approved in 2014 for the treatment of obstructive sleep apnea in patients who are intolerant to continuous positive airway pressure (CPAP) therapy, which is reported in up to 40–60% of patients. This therapy works via direct neurostimulation of the hypoglossal nerve in synchrony with respiration, to open the airway via tongue stiffening and protrusion. Studies have demonstrated significant reductions in both respiratory parameters such as disordered breathing indices, as well as subjective sleep complaints, such as daytime sleepiness, with the use of this therapy. This has increased the repertoire of treatment options for sleep providers to recommend to those patients that are intolerant to CPAP therapy.

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Correspondence to Michael D. Olson.

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Olson, M.D., Junna, M.R. Hypoglossal Nerve Stimulation Therapy for the Treatment of Obstructive Sleep Apnea. Neurotherapeutics (2021). https://doi.org/10.1007/s13311-021-01012-x

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Key Words

  • Hypoglossal nerve stimulation therapy
  • upper airway stimulation
  • surgery
  • obstructive sleep apnea
  • continuous positive airway pressure
  • continue positive airway pressure intolerance