Rettger, L.F., A Treatise on the Transformation of the Intestinal Flora. London: Forgotten Books. (Original work published 1921). (2013).
Shulman, S.T., Friedmann, H.C., and Sims, R.H., Theodor Escherich: the first pediatric infectious diseases physician? Clin Infect Dis, 2007. 45(8): p. 1025-9.
Article
PubMed
Google Scholar
Grice, E.A. and Segre, J.A., The human microbiome: our second genome. Annu Rev Genomics Hum Genet, 2012. 13: p. 151-70.
CAS
Article
PubMed
PubMed Central
Google Scholar
Xu, J. and Gordon, J.I., Honor thy symbionts. Proc Natl Acad Sci U S A, 2003. 100(18): p. 10452-9.
CAS
Article
PubMed
PubMed Central
Google Scholar
O'Hara, A.M. and Shanahan, F., The gut flora as a forgotten organ. EMBO Rep, 2006. 7(7): p. 688-93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Borre, Y.E., O'Keeffe, G.W., Clarke, G., Stanton, C., Dinan, T.G., and Cryan, J.F., Microbiota and neurodevelopmental windows: implications for brain disorders. Trends Mol Med, 2014. 20(9): p. 509-18.
Article
PubMed
Google Scholar
Butto, L.F. and Haller, D., Dysbiosis in intestinal inflammation: Cause or consequence. Int J Med Microbiol, 2016.
Karlsson, F.H., Tremaroli, V., Nookaew, I., et al., Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature, 2013. 498(7452): p. 99-103.
CAS
Article
PubMed
Google Scholar
Bultman, S.J., Emerging roles of the microbiome in cancer. Carcinogenesis, 2014. 35(2): p. 249-55.
CAS
Article
PubMed
Google Scholar
Mayer, E.A., Knight, R., Mazmanian, S.K., Cryan, J.F., and Tillisch, K., Gut microbes and the brain: paradigm shift in neuroscience. J Neurosci, 2014. 34(46): p. 15490-6.
Article
PubMed
PubMed Central
Google Scholar
Scheperjans, F., Aho, V., Pereira, P.A., et al., Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov Disord, 2015. 30(3): p. 350-8.
Article
PubMed
Google Scholar
Gungor, B., Adiguzel, E., Gursel, I., Yilmaz, B., and Gursel, M., Intestinal Microbiota in Patients with Spinal Cord Injury. PLoS One, 2016. 11(1): p. e0145878.
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., and Gobbetti, M., Autism spectrum disorders and intestinal microbiota. Gut Microbes, 2015. 6(3): p. 207-13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yin, J., Liao, S.X., He, Y., et al., Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. J Am Heart Assoc, 2015. 4(11).
Houlden, A., Goldrick, M., Brough, D., et al., Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production. Brain Behav Immun, 2016.
Singh, V., Roth, S., Llovera, G., et al., Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke. J Neurosci, 2016. 36(28): p. 7428-40.
CAS
Article
PubMed
Google Scholar
O'Toole, P.W. and Claesson, M.J., Gut microbiota: Changes throughout the lifespan from infancy to elderly. International Dairy Journal, 2010. 20(4): p. 281-291.
Article
CAS
Google Scholar
Claesson, M.J., Cusack, S., O'Sullivan, O., et al., Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A, 2011. 108 Suppl 1: p. 4586-91.
CAS
Article
PubMed
Google Scholar
Reardon, S., Microbiome therapy gains market traction. Nature, 2014. 509(7500): p. 269-70.
CAS
Article
PubMed
Google Scholar
Garber, K., Drugging the gut microbiome. Nat Biotechnol, 2015. 33(3): p. 228-31.
CAS
Article
PubMed
Google Scholar
Luczynski, P., McVey Neufeld, K.A., Oriach, C.S., Clarke, G., Dinan, T.G., and Cryan, J.F., Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior. Int J Neuropsychopharmacol, 2016.
Collins, J., Borojevic, R., Verdu, E.F., Huizinga, J.D., and Ratcliffe, E.M., Intestinal microbiota influence the early postnatal development of the enteric nervous system. Neurogastroenterol Motil, 2014. 26(1): p. 98-107.
CAS
Article
PubMed
Google Scholar
Braniste, V., Al-Asmakh, M., Kowal, C., et al., The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med, 2014. 6(263): p. 263ra158.
Erny, D., Hrabe de Angelis, A.L., Jaitin, D., et al., Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci, 2015. 18(7): p. 965-77.
CAS
Article
PubMed
Google Scholar
Hoban, A.E., Stilling, R.M., Ryan, F.J., et al., Regulation of prefrontal cortex myelination by the microbiota. Transl Psychiatry, 2016. 6: p. e774.
Heijtz, R.D., Wang, S., Anuar, F., et al., Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences of the United States of America, 2011. 108(7): p. 3047-52.
CAS
Article
PubMed Central
Google Scholar
Sudo, N., Chida, Y., Aiba, Y., et al., Postnatal microbial colonization programs the hypothalamic-pituitaryadrenal system for stress response in mice. J Physiol, 2004. 558(Pt 1): p. 263-75.
CAS
Article
PubMed
PubMed Central
Google Scholar
Gareau, M.G., Wine, E., Rodrigues, D.M., et al., Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 2010.
Bercik, P., Denou, E., Collins, J., et al., The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice. Gastroenterology, 2011.
Bruce-Keller, A.J., Salbaum, J.M., Luo, M., et al., Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity. Biol Psychiatry, 2015. 77(7): p. 607-15.
Article
PubMed
Google Scholar
Neufeld, K.M., Kang, N., Bienenstock, J., and Foster, J.A., Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil, 2011. 23(3): p. 255-64, e119.
CAS
Article
PubMed
Google Scholar
Binder, D.K. and Scharfman, H.E., Brain-derived neurotrophic factor. Growth Factors, 2004. 22(3): p. 123-31.
CAS
Article
PubMed
PubMed Central
Google Scholar
Clarke, G., Grenham, S., Scully, P., et al., The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry, 2012.
Yano, J.M., Yu, K., Donaldson, G.P., et al., Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 2015. 161(2): p. 264-76.
CAS
Article
PubMed
PubMed Central
Google Scholar
Wikoff, W.R., Anfora, A.T., Liu, J., et al., Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A, 2009. 106(10): p. 3698-703.
CAS
Article
PubMed
PubMed Central
Google Scholar
Collins, S.M., Surette, M., and Bercik, P., The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol, 2012. 10(11): p. 735-42.
CAS
Article
PubMed
Google Scholar
Cryan, J.F. and Dinan, T.G., Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci, 2012. 13(10): p. 701-12.
CAS
Article
PubMed
Google Scholar
Rhee, S.H., Pothoulakis, C., and Mayer, E.A., Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol, 2009. 6(5): p. 306-14.
CAS
Article
PubMed
Google Scholar
Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., and Nagai, K., Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethaneanesthetized rats. Neurosci Lett, 2005. 389(2): p. 109-14.
CAS
Article
PubMed
Google Scholar
Bravo, J.A., Forsythe, P., Chew, M.V., et al., Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A, 2011. 108(38): p. 16050-5.
CAS
Article
PubMed
PubMed Central
Google Scholar
Bercik, P., Park, A.J., Sinclair, D., et al., The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil, 2011. 23(12): p. 1132-9.
CAS
Article
PubMed
PubMed Central
Google Scholar
Ochoa-Reparaz, J., Mielcarz, D.W., Begum-Haque, S., and Kasper, L.H., Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease. Ann Neurol, 2011. 69(2): p. 240-7.
CAS
Article
PubMed
Google Scholar
Wang, Y. and Kasper, L.H., The role of microbiome in central nervous system disorders. Brain Behav Immun, 2014. 38: p. 1-12.
Article
CAS
PubMed
Google Scholar
Mayer, E.A., Tillisch, K., and Gupta, A., Gut/brain axis and the microbiota. J Clin Invest, 2015. 125(3): p. 926-38.
Article
PubMed
PubMed Central
Google Scholar
Berer, K., Mues, M., Koutrolos, M., et al., Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature, 2011. 479(7374): p. 538-41.
CAS
Article
PubMed
Google Scholar
Lee, Y.K., Menezes, J.S., Umesaki, Y., and Mazmanian, S.K., Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A, 2011. 108 Suppl 1: p. 4615-22.
CAS
Article
PubMed
Google Scholar
Bettelli, E., Pagany, M., Weiner, H.L., Linington, C., Sobel, R.A., and Kuchroo, V.K., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med, 2003. 197(9): p. 1073-81.
CAS
Article
PubMed
PubMed Central
Google Scholar
Miller, P.G., Bonn, M.B., Franklin, C.L., Ericsson, A.C., and McKarns, S.C., TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease. J Immunol, 2015. 195(10): p. 4668-84.
CAS
Article
PubMed
Google Scholar
Nouri, M., Bredberg, A., Westrom, B., and Lavasani, S., Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of autoreactive T cells. PLoS One, 2014. 9(9): p. e106335.
Rothhammer, V., Mascanfroni, I.D., Bunse, L., et al., Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med, 2016.
Ochoa-Reparaz, J., Mielcarz, D.W., Wang, Y., et al., A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease. Mucosal Immunology, 2010. 3(5): p. 487-495.
CAS
Article
PubMed
Google Scholar
Mazmanian, S.K., Liu, C.H., Tzianabos, A.O., and Kasper, D.L., An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell, 2005. 122(1): p. 107-18.
CAS
Article
PubMed
Google Scholar
Hsiao, E.Y., McBride, S.W., Hsien, S., et al., Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell, 2013. 155(7): p. 1451-63.
CAS
Article
PubMed
PubMed Central
Google Scholar
Tennoune, N., Chan, P., Breton, J., et al., Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide alpha-MSH, at the origin of eating disorders. Transl Psychiatry, 2014. 4: p. e458.
Park, A.J., Collins, J., Blennerhassett, P.A., et al., Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil, 2013. 25(9): p. 733-e575.
CAS
Article
PubMed
PubMed Central
Google Scholar
O'Mahony, S.M., Marchesi, J.R., Scully, P., et al., Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry, 2009. 65(3): p. 263-7.
Article
PubMed
Google Scholar
De Palma, G., Blennerhassett, P., Lu, J., et al., Microbiota and host determinants of behavioural phenotype in maternally separated mice. Nat Commun, 2015. 6: p. 7735.
Article
CAS
PubMed
Google Scholar
Harach, T.M., N.; Dutilleul, N.; Cheatham, V., et al., Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota. arXiv:1509.02273v2 [q-bio.MN].
Minter, M.R., Zhang, C., Leone, V., et al., Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease. Sci Rep, 2016. 6: p. 30028.
Article
PubMed
PubMed Central
Google Scholar
Jandzinski, M., Manipulation of the microbiome and its impact on functional recovery following ischemic stroke. Honors Scholar Theses. Paper 414, 2015: p. http://digitalcommons.uconn.edu/srhonors_theses/414.
Tascilar, N., Irkorucu, O., Tascilar, O., et al., Bacterial translocation in experimental stroke: what happens to the gut barrier? Bratisl Lek Listy, 2010. 111(4): p. 194-9.
PubMed
Google Scholar
Caso, J.R., Hurtado, O., Pereira, M.P., et al., Colonic bacterial translocation as a possible factor in stressworsening experimental stroke outcome. Am J Physiol Regul Integr Comp Physiol, 2009. 296(4): p. R979-85.
CAS
Article
PubMed
Google Scholar
Whittaker, R.H., Evolution and Measurement of Species Diversity. Taxon, 1972. 21(2/3 ): p. 213-251.
Article
Google Scholar
Benakis, C., Brea, D., Caballero, S., et al., Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells. Nat Med, 2016. 22(5): p. 516-23.
CAS
Article
PubMed
PubMed Central
Google Scholar
Garidou, L., Pomie, C., Klopp, P., et al., The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORgammat and Controls Metabolic Disease. Cell Metab, 2015. 22(1): p. 100-12.
CAS
Article
PubMed
Google Scholar
Sacco, R.L., Benjamin, E.J., Broderick, J.P., et al., American Heart Association Prevention Conference. IV. Prevention and Rehabilitation of Stroke. Risk factors. Stroke, 1997. 28(7): p. 1507-17.
CAS
Article
PubMed
Google Scholar
Winek, K., Engel, O., Koduah, P., et al., Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke. Stroke, 2016. 47(5): p. 1354-63.
CAS
Article
PubMed
PubMed Central
Google Scholar
Meisel, C., Schwab, J.M., Prass, K., Meisel, A., and Dirnagl, U., Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci, 2005. 6(10): p. 775-86.
CAS
Article
PubMed
Google Scholar
Schulte-Herbruggen, O., Quarcoo, D., Meisel, A., and Meisel, C., Differential affection of intestinal immune cell populations after cerebral ischemia in mice. Neuroimmunomodulation, 2009. 16(3): p. 213-8.
Article
CAS
PubMed
Google Scholar
Sun, J., Wang, F., Ling, Z., et al., Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota. Brain Res, 2016.
Winek, K., Meisel, A., and Dirnagl, U., Gut microbiota impact on stroke outcome: Fad or fact? J Cereb Blood Flow Metab, 2016. 36(5): p. 891-8.
Article
PubMed
Google Scholar
Felice, V.D., Quigley, E.M., Sullivan, A.M., O'Keeffe, G.W., and O'Mahony, S.M., Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms. Parkinsonism Relat Disord, 2016.
Chen, J., Chia, N., Kalari, K.R., et al., Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep, 2016. 6: p. 28484.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jangi, S., Gandhi, R., Cox, L.M., et al., Alterations of the human gut microbiome in multiple sclerosis. Nat Commun, 2016. 7: p. 12015.
CAS
Article
PubMed
PubMed Central
Google Scholar
Swidsinski, A.L.-B., V.; Krüger, M.; Kirsch, S., Central Nervous System and the Colonic Bioreactor: Analysis of Colonic Microbiota in Patients with Stroke Unravels Unknown Mechanisms of the Host Defense after Brain Injury. Intest Res, 2012. 10(4): p. 332-342.
Article
Google Scholar
Zhu, W., Gregory, J.C., Org, E., et al., Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell, 2016. 165(1): p. 111-24.
CAS
Article
PubMed
Google Scholar
Wang, Z., Klipfell, E., Bennett, B.J., et al., Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature, 2011. 472(7341): p. 57-63.
CAS
Article
PubMed
PubMed Central
Google Scholar
Koren, O., Spor, A., Felin, J., et al., Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A, 2010. 108 Suppl 1: p. 4592-8.
PubMed
PubMed Central
Google Scholar
Tang, W.H., Wang, Z., Levison, B.S., et al., Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med, 2013. 368(17): p. 1575-84.
CAS
Article
PubMed
PubMed Central
Google Scholar
Koeth, R.A., Wang, Z., Levison, B.S., et al., Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med, 2013. 19(5): p. 576-85.
CAS
Article
PubMed
PubMed Central
Google Scholar
Karlsson, F.H., Fak, F., Nookaew, I., et al., Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun, 2012. 3: p. 1245.
Article
CAS
PubMed
PubMed Central
Google Scholar
Skagen, K., Troseid, M., Ueland, T., et al., The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis. Atherosclerosis, 2016. 247: p. 64-9.
CAS
Article
PubMed
Google Scholar
Meir, K.S. and Leitersdorf, E., Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress. Arterioscler Thromb Vasc Biol, 2004. 24(6): p. 1006-14.
CAS
Article
PubMed
Google Scholar
Collins, H.L., Drazul-Schrader, D., Sulpizio, A.C., et al., L-Carnitine intake and high trimethylamine Noxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP. Atherosclerosis, 2016. 244: p. 29-37.
CAS
Article
PubMed
Google Scholar
Stepankova, R., Tonar, Z., Bartova, J., et al., Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet. J Atheroscler Thromb, 2010. 17(8): p. 796-804.
CAS
Article
PubMed
Google Scholar
Singh, V., Yeoh, B.S., and Vijay-Kumar, M., Gut microbiome as a novel cardiovascular therapeutic target. Curr Opin Pharmacol, 2016. 27: p. 8-12.
CAS
Article
PubMed
Google Scholar
Hartstra, A.V., Bouter, K.E., Backhed, F., and Nieuwdorp, M., Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care, 2015. 38(1): p. 159-65.
CAS
Article
PubMed
Google Scholar
Turnbaugh, P.J., Hamady, M., Yatsunenko, T., et al., A core gut microbiome in obese and lean twins. Nature, 2009. 457(7228): p. 480-4.
CAS
Article
PubMed
Google Scholar
Backhed, F., Ding, H., Wang, T., et al., The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A, 2004. 101(44): p. 15718-23.
Article
CAS
PubMed
PubMed Central
Google Scholar
Backhed, F., Manchester, J.K., Semenkovich, C.F., and Gordon, J.I., Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A, 2007. 104(3): p. 979-84.
CAS
Article
PubMed
PubMed Central
Google Scholar
Fu, J., Bonder, M.J., Cenit, M.C., et al., The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids. Circ Res, 2015. 117(9): p. 817-24.
CAS
Article
PubMed
PubMed Central
Google Scholar
Durgan, D.J., Ganesh, B.P., Cope, J.L., et al., Role of the Gut Microbiome in Obstructive Sleep Apnea- Induced Hypertension. Hypertension, 2016. 67(2): p. 469-74.
CAS
PubMed
Google Scholar
Santisteban, M.M., Kim, S., Pepine, C.J., and Raizada, M.K., Brain-Gut-Bone Marrow Axis: Implications for Hypertension and Related Therapeutics. Circ Res, 2016. 118(8): p. 1327-36.
CAS
Article
PubMed
Google Scholar
Wang, Z., Roberts, A.B., Buffa, J.A., et al., Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell, 2015. 163(7): p. 1585-95.
CAS
Article
PubMed
Google Scholar
Langhorne, P., Stott, D.J., Robertson, L., et al., Medical complications after stroke: a multicenter study. Stroke, 2000. 31(6): p. 1223-9.
CAS
Article
PubMed
Google Scholar
Westendorp, W.F., Nederkoorn, P.J., Vermeij, J.D., Dijkgraaf, M.G., and de Beek, D., Post-stroke infection: A systematic review and meta-analysis. BMC neurology, 2011. 11: p. 110.
Article
PubMed
PubMed Central
Google Scholar
Latorre, M., Krishnareddy, S., and Freedberg, D.E., Microbiome as mediator: Do systemic infections start in the gut? World J Gastroenterol, 2015. 21(37): p. 10487-92.
CAS
Article
PubMed
PubMed Central
Google Scholar
Schuijt, T.J., Lankelma, J.M., Scicluna, B.P., et al., The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia. Gut, 2016. 65(4): p. 575-83.
Article
PubMed
Google Scholar
Dickson, R.P. and Cox, M.J., The premature invocation of a 'gut-lung axis' may obscure the direct effects of respiratory microbiota on pneumonia susceptibility. Gut, 2016.
Langdon, A., Crook, N., and Dantas, G., The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med, 2016. 8(1): p. 39.
Article
PubMed
PubMed Central
Google Scholar
Jernberg, C., Lofmark, S., Edlund, C., and Jansson, J.K., Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. ISME J, 2007. 1(1): p. 56-66.
CAS
Article
PubMed
Google Scholar
Meisel, A. and Smith, C.J., Prevention of stroke-associated pneumonia: where next? Lancet, 2015.
Springer, J., Schust, S., Peske, K., et al., Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia. Stroke, 2014. 45(12): p. 3675-83.
CAS
Article
PubMed
Google Scholar
Scherbakov, N., Dirnagl, U., and Doehner, W., Body weight after stroke: lessons from the obesity paradox. Stroke; a journal of cerebral circulation, 2011. 42(12): p. 3646-50.
Article
PubMed
Google Scholar
Turnbaugh, P.J., Backhed, F., Fulton, L., and Gordon, J.I., Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe, 2008. 3(4): p. 213-23.
CAS
Article
PubMed
PubMed Central
Google Scholar
Bindels, L.B., Beck, R., Schakman, O., et al., Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model. PLoS One, 2012. 7(6): p. e37971.
Robinson, R.G. and Jorge, R.E., Post-Stroke Depression: A Review. Am J Psychiatry, 2016. 173(3): p. 221-31.
Article
PubMed
Google Scholar
Fetissov, S.O. and Dechelotte, P., The new link between gut-brain axis and neuropsychiatric disorders. Curr Opin Clin Nutr Metab Care, 2011. 14(5): p. 477-82.
Article
PubMed
Google Scholar
Yarandi, S.S., Peterson, D.A., Treisman, G.J., Moran, T.H., and Pasricha, P.J., Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases. J Neurogastroenterol Motil, 2016. 22(2): p. 201-12.
Article
PubMed
PubMed Central
Google Scholar
Forsythe, P., Sudo, N., Dinan, T., Taylor, V.H., and Bienenstock, J., Mood and gut feelings. Brain Behav Immun, 2010. 24(1): p. 9-16.
Article
PubMed
Google Scholar
Jiang, H., Ling, Z., Zhang, Y., et al., Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun, 2015. 48: p. 186-94.
Article
PubMed
Google Scholar
Jia, W., Li, H., Zhao, L., and Nicholson, J.K., Gut microbiota: a potential new territory for drug targeting. Nat Rev Drug Discov, 2008. 7(2): p. 123-9.
CAS
Article
PubMed
Google Scholar
Ashraf, R. and Shah, N.P., Immune system stimulation by probiotic microorganisms. Crit Rev Food Sci Nutr, 2014. 54(7): p. 938-56.
CAS
Article
PubMed
Google Scholar
Besselink, M.G., van Santvoort, H.C., Renooij, W., et al., Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis. Ann Surg, 2009. 250(5): p. 712-9.
Article
PubMed
Google Scholar
Gooszen, H.G. and Dutch Pancreatitis Study, G., The PROPATRIA trial: best practices at the time were followed. Lancet, 2010. 375(9722): p. 1249-50.
Article
PubMed
Google Scholar
Dani, C., Coviello, C.C., Corsini, I.I., Arena, F., Antonelli, A., and Rossolini, G.M., Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review. AJP Rep, 2016. 6(1): p. e25-9.
PubMed
Google Scholar
Oggioni, M.R., Pozzi, G., Valensin, P.E., Galieni, P., and Bigazzi, C., Recurrent septicemia in an immunocompromised patient due to probiotic strains of Bacillus subtilis. J Clin Microbiol, 1998. 36(1): p. 325-6.
CAS
PubMed
PubMed Central
Google Scholar
Kochan, P., Chmielarczyk, A., Szymaniak, L., et al., Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient--is the time right to revise probiotic safety guidelines? Clin Microbiol Infect, 2011. 17(10): p. 1589-92.
CAS
Article
PubMed
Google Scholar
Eiseman, B., Silen, W., Bascom, G.S., and Kauvar, A.J., Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis. Surgery, 1958. 44(5): p. 854-9.
CAS
PubMed
Google Scholar
van Nood, E., Vrieze, A., Nieuwdorp, M., et al., Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med, 2013. 368(5): p. 407-15.
Article
CAS
PubMed
Google Scholar
Vermeire, S., Joossens, M., Verbeke, K., et al., Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease. J Crohns Colitis, 2016. 10(4): p. 387-94.
Petrof, E.O., Gloor, G.B., Vanner, S.J., et al., Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome, 2013. 1(1): p. 3.
Didesch, M.M., Averill, A., and Oh-Park, M., Peripheral Neuropathy After Fecal Microbiota Transplantation for Clostridium difficile Infection: A Case Report. PM R, 2016.
Gregory, J.C., Buffa, J.A., Org, E., et al., Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem, 2015. 290(9): p. 5647-60.
CAS
Article
PubMed
Google Scholar
Perie-FlomCenter, Bill of Health http://blogs.harvard.edu/billofhealth/2016/03/01/fda-announces-draftguidance-that-would-limit-enforcement-discretion-for-fmt. Accessed on 29th of March 2016.
Belizario, J.E. and Napolitano, M., Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches. Front Microbiol, 2015. 6: p. 1050.
Article
PubMed
PubMed Central
Google Scholar
Chow, J. and Mazmanian, S.K., Getting the bugs out of the immune system: do bacterial microbiota "fix" intestinal T cell responses? Cell Host Microbe, 2009. 5(1): p. 8-12.
CAS
Article
PubMed
Google Scholar
Maslowski, K.M., Vieira, A.T., Ng, A., et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 2009. 461(7268): p. 1282-6.
CAS
Article
PubMed
PubMed Central
Google Scholar
Spanogiannopoulos, P., Bess, E.N., Carmody, R.N., and Turnbaugh, P.J. The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism. Nat Rev Microbiol, 2016. 14(5): p. 273-87.
CAS
Article
PubMed
Google Scholar
Sousa, T., Paterson, R., Moore, V., Carlsson, A., Abrahamsson, B., and Basit, A.W. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm, 2008. 363(1-2): p. 1-25.
CAS
Article
PubMed
Google Scholar
Haiser, H.J. and Turnbaugh, P.J. Is it time for a metagenomic basis of therapeutics? Science, 2012. 336(6086): p. 1253-5.
CAS
Article
PubMed
Google Scholar
Wallace, B.D., Wang, H., Lane, K.T., et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science, 2010. 330(6005): p. 831-5.
CAS
Article
PubMed
PubMed Central
Google Scholar
Vetizou, M., Pitt, J.M., Daillere, R., et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science, 2015. 350(6264): p. 1079-84.
CAS
Article
PubMed
PubMed Central
Google Scholar
Sivan, A., Corrales, L., Hubert, N., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science, 2015. 350(6264): p. 1084-9.
CAS
Article
PubMed
PubMed Central
Google Scholar
Lemon, K.P., Armitage, G.C., Relman, D.A., and Fischbach, M.A. Microbiota-targeted therapies: an ecological perspective. Sci Transl Med, 2012. 4(137): p. 137rv5.
Kleiman, S.C., Watson, H.J., Bulik-Sullivan, E.C., et al. The intestinal microbiota in acute anorexia nervosa and during renourishment: relationship to depression, anxiety, and eating disorder psychopathology. Psychosom Med, 2015. 77(9): p. 969- 981.
Article
PubMed
Google Scholar
Krajmalnik-Brown, R., Lozupone, C., Kang, D.W., and Adams, J.B. Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease. Microb Ecol Health Dis 2015. 26: p. 26914.
PubMed
Google Scholar