Abstract
The minimally invasive approach (MIS) is undoubtedly one of the most important breakthroughs in surgery in recent decades. Consequently, MIS has been increasingly in the field of liver transplantation (LT). The objective of the present review was to determine the current status of MIS with respect to liver transplantation (LT) and what would be the indications for an MIS in this context today. The literature was searched for publications reporting the MIS in LT. Only those articles that described the results according to whether the MIS had been performed to treat transplant complications (urgent or late), another pathology not related to the LT, or to perform the liver explantation and graft implantation were included. From 2000 to 2022, 33 studies and 261 patients were included. Most frequent indications were incisional hernias secondary to LT followed by the treatment of other pathologies not related with the LT and treatment of LT complications. Only a 12% were urgent interventions. Few studies describe conversions with an average rate of 2.5%. Morbidity do not differ significantly from open surgery. No case of mortality or graft loss was described. Purely laparoscopic liver explants in 9 patients with 2 conversions and 3 cases of graft implantation with a higher warm ischemia in the MIS implants grafts were described. The limitations of MIS in LT are relative and probably depend more on training, experience, and skills of the surgeons. This approach could be safety and feasibility to solved complications or in other individualized indications in LT patients. The initial experiences in liver explant and graft implantation need further investigations.
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The authors and collaborators confrm that the data supporting the fndings of this study are available within the article and its supplementary material. Raw data that support the fndings of this study are available from the corresponding author, upon request.
References
Rudiman R (2021) Minimally invasive gastrointestinal surgery: From past to the future. Ann Med Surg (Lond) 71:102922. https://doi.org/10.1016/j.amsu.2021.102922
Tsui C, Klein R, Garabrant M (2013) Minimally invasive surgery: national trends in adoption and future directions for hospital strategy. Surg Endosc 27:2253–2257. https://doi.org/10.1007/s00464-013-2973-9
Pedano N, Rotellar F, Alvarez-Cienfuegos J, Arredondo J, Bellver M, Martínez P, Sánchez C, Martí P, Zozaya G, Herrero JI, Pardo F (2012) Efficacy of laparoscopic approach in the management of early liver transplant complications. Transpl Proc 44:1560–1561. https://doi.org/10.1016/j.transproceed.2012.05.024
Feldbrügge L, Wabitsch S, Benzing C, Krenzien F, Kästner A, Haber PK, Atanasov G, Andreou A, Öllinger R, Pratschke J, Schmelzle M (2020) Safety and feasibility of laparoscopic liver resection in patients with a history of abdominal surgeries. HPB 22:1191–1196. https://doi.org/10.1016/j.hpb.2019.11.006
Lopez-Lopez V, Gómez Ruiz A, Pelegrin P, Abellán B, Lopez-Conesa A, Brusadin R, Cayuela V, García A, Robles Campos R (2021) Impact of immune response in short-term and long-term outcomes after minimally invasive surgery for colorectal liver metastases: results from a randomized study. Surgical Laparoscopy, Endoscopy Percutaneous Techniques 31:690–696. https://doi.org/10.1097/SLE.0000000000000980
Dokmak S, Cauchy F, Sepulveda A, Choinier PM, Dondéro F, Aussilhou B, Hego C, Chopinet S, Infantes P, Weiss E, Francoz C, Sauvanet A, Paugam-Burtz C, Durand F, Soubrane O (2020) Laparoscopic LT. Ann Surg 272:889–893. https://doi.org/10.1097/SLA.0000000000003751
Suh K, Hong SK, Hong K, Han ES, Hong SY, Suh S, Lee J, Choi Y, Yi N, Lee K, (2021) Minimally invasive living donor lt: pure laparoscopic explant hepatectomy and graft implantation using upper midline incision. LT https://doi.org/10.1002/lt.26066
Suh K, Hong SK, Lee S, Young HS, Suh S, Han ES, Yang S, Choi Y, Yi N, Lee K (2022) Pure laparoscopic living donor LT: dreams come true. Am J Transplantation 22:260–265. https://doi.org/10.1111/ajt.16782
Lee K, Choi Y, Hong SK, Lee S, Hong S Young, Suh S, Han ES, Yi N, Suh K (2022) Laparoscopic donor and recipient hepatectomy followed by robot‐assisted liver graft implantation in living donor LT. American Journal of Transplantation 22:1230–1235. https://doi.org/10.1111/ajt.16943
Suh KS, Hong SK, Lee S, Hong SY, Suh S, Han ES, Yang SM, Choi Y, Yi NJ, Lee KW (2022) Purely laparoscopic explant hepatectomy and hybrid laparoscopic/robotic graft implantation in living donor LT. Br J Surg 109:162–164. https://doi.org/10.1093/bjs/znab322
Gianchandani R, Pérez E, Moneva E, Menéndez A, Sánchez JM, Díaz C, Concepción V, Barrera MA (2020) Laparoscopic incisional hernia repair after lt: long-term series and literature review. Transplant Proc 52:1514–1517. https://doi.org/10.1016/j.transproceed.2020.01.082
Scheuerlein H, Rauchfuss F, Gharbi A, Heise M, Settmacher U (2011) Laparoscopic incisional hernia repair after solid-organ transplantation. Transpl Proc 43:1783–1789. https://doi.org/10.1016/j.transproceed.2011.03.082
Kennealey PT (2009) Laparoscopic incisional hernia repair after solid-organ transplantation. Arch Surg 144:228. https://doi.org/10.1001/archsurg.2008.571
Weiss S, Weissenbacher A, Sucher R, Denecke C, Brandl A, Messner F, Oellinger R, Schneeberger S, Schmid T, Pratschke J, Biebl M (2015) Outcome analysis of laparoscopic incisional hernia repair and risk factors for hernia recurrence in liver transplant patients. Clin Transplant 29:866–871. https://doi.org/10.1111/ctr.12558
Tsamalaidze L, Stauffer JA, Arasi LC, Villacreses DE, Franco JSS, Bowers S, Elli EF (2018) Laparoscopic sleeve Gastrectomy for morbid obesity in patients after orthotopic liver transplant: a matched case-control study. Obes Surg 28:444–450. https://doi.org/10.1007/s11695-017-2847-7
Mekeel K, Mulligan D, Reddy KS, Moss A, Harold K (2007) Laparoscopic incisional hernia repair after. LT 13:1576–1581. https://doi.org/10.1002/lt.21290
Kurmann A, Beldi G, Vorburger SA, Seiler CA, Candinas D (2010) Laparoscopic incisional hernia repair is feasible and safe after LT. Surg Endosc 24:1451–1455. https://doi.org/10.1007/s00464-009-0799-2
Maurette R, Garcia Ejarque M, Silberman E, Bregante M, Bogetti D, Pirchi D (2015) Laparoscopy after liver transplant: result of an initial series. Transpl Proc 47:2499–2503. https://doi.org/10.1016/j.transproceed.2015.08.014
Cos H, Ahmed O, Garcia-Aroz S, Vachharajani N, Shenoy S, Wellen JR, Doyle MMB, Chapman WC, Khan AS (2020) Incisional hernia after LT: Risk factors, management strategies and long-term outcomes of a cohort study. Int J Surg 78:149–153. https://doi.org/10.1016/j.ijsu.2020.04.048
Hegab B, Abdelfattah M, Azzam A, al Sebayel M (2016) The usefulness of laparoscopic hernia repair in the management of incisional hernia following LT. Journal of Minimal Access Surgery 12:58. https://doi.org/10.4103/0972-9941.152102
Merenda R, Gerunda GE, Neri D, Barbazza F, di Marzio E, Meduri F, Valmasoni M, Faccioli AM (2000) Laparoscopic surgery after orthotopic LT. LT 6:104–107. https://doi.org/10.1002/lt.500060101
Sepulveda A, Brustia R, Perdigao F, Soubrane O, Scatton O, (2015) Pure laparoscopic management of early biliary leakage after LT: Abdominal lavage and T-Tube placement. LT https://doi.org/10.1002/lt.24186
Robles-Campos R, Parrilla P, Lujan JA, Torralba JA, Ramírez P, Sánchez-Bueno F (1997) Laparoscopic treatment of biliary peritonitis after T-tube removal in patients undergoing orthotopic LT. Br J Surg 84:1244
Cascales Campos P, Ramírez Romero P, González R, Pons JA, Miras M, Sanchez Bueno F, Robles R, Parrilla P (2012) Laparoscopic treatment of biliary peritonitis after removal of T-tube in liver transplant patients. Transpl Proc 44:1550–1553. https://doi.org/10.1016/j.transproceed.2012.05.018
Hawksworth J, Radkani P, Nguyen B, Aguirre O, Winslow E, Kroemer A, Girlanda R, Guerra JF, Haddad N, Fishbein T (2022) Robotic hepaticojejunostomy for late anastomotic biliary stricture after LT. Ann Surg 275:e801–e803. https://doi.org/10.1097/SLA.0000000000005303
Lopez-Lopez V, Ruiz-Manzanera JJ, Eshmuminov D, Lehmann K, Schneider M, von der Groeben M, de Angulo DR, Gajownik U, Pons JA, Sánchez-Bueno F, Robles-Campos R, Ramírez-Romero P (2021) Are We Ready for Bariatric Surgery in a Liver Transplant Program? A Meta-Analysis. Obes Surg 31:1214–1222. https://doi.org/10.1007/s11695-020-05118-7
DeRoover A, Sudan D (2001) Treatment of multiple aneurysms of the splenic artery after LT by percutaneous embolization and laparoscopic splenectomy. Transplantation 72:956–958. https://doi.org/10.1097/00007890-200109150-00036
Uehara H, Kawanaka H, Akahoshi T, Tomikawa M, Kinjo N, Hashimoto N, Ikegami T, Soejima Y, Taketomi A, Maehara Y (2009) The feasibility and effectiveness of a hand-assisted laparoscopic splenectomy for hypersplenism in patients after living-donor LT. Surg Laparoscopy, Endoscopy Percutaneous Techni 19:484–487. https://doi.org/10.1097/SLE.0b013e3181bc3f90
Gill IS, Meraney AM, Mayes JT, Bravo EL (2001) Laparoscopic right adrenalectomy after LT. Transplantation 71:1350–1351. https://doi.org/10.1097/00007890-200105150-00032
Zhu H-B, Jin Y, Xu S-T, Xia Y-X, Xie L-P (2010) Total laparoscopic hysterectomy after LT. Hepatobiliary Pancreat Dis Int 9:438–440
Yin WY (2014) Acute appendicitis in organ transplantation patients: a report of two cases and a literature review. Annals Transplant 19:248–252. https://doi.org/10.1259/AOT.890418
Sahakyan MA, Kazaryan AM, Pomianowska E, Abildgaard A, Line P-D, Bjørnbeth BA, Edwin B, Røsok BI (2016) Laparoscopic resection of recurrence from hepatocellular carcinoma after LT: case reports and review of the literature. Case Rep Oncol Med 2016:1–5. https://doi.org/10.1155/2016/8946471
Colasanti M, Berardi G, Mariano G, Ferretti S, Meniconi RL, Guglielmo N, Ettorre GM (2022) Laparoscopic Left hepatectomy for hepatocellular carcinoma recurrence following LT. Ann Surg Oncol 29:2984–2984. https://doi.org/10.1245/s10434-021-11275-5
Zani A, Paul A, Dhawan A, Desai A (2014) Is single-port laparoscopy feasible after liver transplant? Pediatr Transplant 18:163–165. https://doi.org/10.1111/petr.12212
Hochman DJ, Pemberton JH (2007) Hand-assisted laparoscopic total proctocolectomy and ileal pouch-anal anastomosis after liver transplant for primary sclerosing cholangitis. Surgical Laparoscopy, Endoscopy Percutaneous Techn 17:56–57. https://doi.org/10.1097/01.sle.0000213764.48052.f1
Darnis B, Poncet G, Robert M (2017) Laparoscopic total colectomy for ulcerative colitis after LT is feasible. J Minimal Access Surg. https://doi.org/10.4103/0972-9941.199211
Bertelli R, Prosperi E, Faccani E, Ansaloni L (2021) Laparoscopic right colectomy for colon cancer after LT. J Minimal Access Surg 17:268. https://doi.org/10.4103/jmas.JMAS_134_20
Lin MYC, Tavakol MM, Sarin A, Amirkiai SM, Rogers SJ, Carter JT, Posselt AM (2013) Safety and feasibility of sleeve gastrectomy in morbidly obese patients following LT. Surg Endosc 27:81–85. https://doi.org/10.1007/s00464-012-2410-5
Cucchetti A, Aldrighetti L, Ratti F, Ferrero A, Guglielmi A, Giuliante F, Cillo U, Mazzaferro V, De Carlis L, Ercolani G, I Go MILS Group (2022) Variations in risk-adjusted outcomes following 4318 laparoscopic liver resections. J Hepatobiliary Pancreat Sci 29(5):521–530. https://doi.org/10.1002/jhbp.1141
Serenari M, Lenzi J, Cucchetti A, Cipriani F, Donadon M, Ardito F, Fazio F, Nicolini D, Iaria M, Famularo S, Perri P, Ansaloni L, Zanello M, Lai Q, Conci S, Molfino S, Ferrari C, Germani P, Zago M, Romano M, Zimmitti G, Antonucci A, Fumagalli L, Troci A, Ferraro V, Memeo R, Crespi M, Chiarelli M, Ercolani G, Hilal MA, Zanus G, Pinotti E, Tarchi P, Griseri G, Baiocchi GL, Ruzzenente A, Rossi M, Jovine E, Maestri M, Grazi GL, Romano F, Dalla Valle R, Ravaioli M, Vivarelli M, Ferrero A, Giuliante F, Torzilli G, Aldrighetti L (2022) The effect of a liver transplant program on the outcomes of resectable hepatocellular carcinoma: a nationwide multicenter analysis. Ann Surg. https://doi.org/10.1097/SLA.0000000000005439
Choi HJ, You YK, Na GH, Hong TH, Shetty GS, Kim DG (2012) Single-port laparoscopy-assisted donor right hepatectomy in living donor lt: sensible approach or unnecessary hindrance? Transpl Proc 44:347–352. https://doi.org/10.1016/j.transproceed.2012.01.018
Koffron AJ, Kung R, Baker T, Fryer J, Clark L, Abecassis M (2006) Laparoscopic-assisted right lobe donor hepatectomy. Am J Transplant 6:2522–2525. https://doi.org/10.1111/j.1600-6143.2006.01498.x
Lambrecht JR, Skauby M, Trondsen E, Vaktskjold A, Øyen OM (2014) Laparoscopic repair of incisional hernia in solid organ-transplanted patients: the method of choice? Transpl Int 27:712–720. https://doi.org/10.1111/tri.12327
Garmpis N, Spartalis E, Schizas D, Patsouras D, Damaskos C, Spartalis M, Garmpi A, Nikiteas NI, Dimitroulis D (2019) Incisional hernias post LT: current evidence of epidemiology risk factors and laparoscopic versus open repair a review of the literature. In Vivo. https://doi.org/10.2173/invivo.11574
de Lima ML, Cotrim CAC, Moro JC, Miyaoka R, D’Ancona CAL (2012) Laparoscopic treatment of lymphoceles after renal transplantation. Int Braz J Urol 38:215–221. https://doi.org/10.1590/S1677-55382012000200009
Ratti F, Cipriani F, Fiorentini G, Catena M, Paganelli M, Aldrighetti L (2020) Reappraisal of the advantages of laparoscopic liver resection for intermediate hepatocellular carcinoma within a stage migration perspective: propensity score analysis of the differential benefit. J Hepatobiliary Pancreat Sci 27(8):510–521. https://doi.org/10.1002/jhbp.736
Acknowledgements
We would like to thank professors Ricardo Robles-Campos and Francisco Sánchez-Bueno, and the entire nursing team of the liver transplant unit for their collaboration.
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T Víctor López-López, María Ángeles Martínez-Serrano, Juan José Ruiz-Manzanera, Dilmurodjon Eshmuminov, and Pablo Ramirez have no conflicts of interest or financial ties to disclose.
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López-López, V., Martínez-Serrano, M.Á., Ruiz-Manzanera, J.J. et al. Minimally invasive surgery and liver transplantation: is it a safe, feasible, and effective approach?. Updates Surg 75, 807–816 (2023). https://doi.org/10.1007/s13304-023-01506-7
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DOI: https://doi.org/10.1007/s13304-023-01506-7