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Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry

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A Correction to this article was published on 29 October 2021

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Abstract

Laparoscopic liver resection (LLR) for Hepatocellular carcinoma (HCC) is a safe procedure. Repeat surgery is more often required, and the role of minimally invasive liver surgery (MILS) is not yet clearly defined. The present study analyzes data compiled by the Italian Group of Minimally Invasive Liver Surgery (IGoMILS) on LLR. To compare repeated LLR with the first LLR for HCC is the primary endpoint. The secondary endpoint was to evaluate the outcome of repeat LLR in the case of primary open versus primary MILS surgery. The data cohort is divided into two groups. Group 1: first liver resection and Group 2: Repeat LLR. To compare the two groups a 3:1 Propensity Score Matching is performed to analyze open versus MILS primary resection. Fifty-two centers were involved in the present study, and 1054 patients were enrolled. 80 patients underwent to a repeat LLR. The type of resection was different, with more major resections in the group 1 before matching the two groups. After propensity score matching 3:1, each group consisted of 222 and 74 patients. No difference between the two groups was observed. In the subgroup analysis, in 44 patients the first resection was performed by an open approach. The other 36 patients were resected with a MILS approach. We found no difference between these two subgroups of patients. The present study in repeat MILS for HCC using the IGoMILS Registry has observed the feasibility and safety of the MILS procedure.

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Acknowlegement

Adelmo Antonucci, Policlinico di Monza, Monza;Giacomo Batignani, Università degli Studi, Firenze.Giulio Belli, Ospedale SM Loreto Nuovo, Napoli;Andrea Belli, Napoli Stefano Berti, Ospedale Civile S.Andrea, La Spezia;Ugo Boggi, AOU Pisana, Pisa;Pasquale Bonsignore, IRCCS-ISMETT, Palermo;Alberto Brolese, Ospedale S.Chiara, Trento; Fulvio Calise, Ospedale Pinetagrande, Castel Volturno;Graziano Ceccarelli, Ospedale San Donato, Arezzo;Sara Cecconi, Parma University Hospital, Parma;Michele Colledan, AO Papa Giovanni XXIII, Bergamo; Andrea Coratti, AOU Careggi, Firenze;Giorgio Ercolani, Forlì.Fabio Ferla, ASST Grande Ospedale Metropolitano Niguarda, Milan;Mauro Filauro, Genova.Antonio Floridi, AO Ospedale Maggiore, Crema; Antonio Frena, Ospedale Centrale, Bolzano;Antonio Giuliani, AO R.N. Cardarelli, Napoli;Felice Giuliante, Policlinico Gemelli, Rome;Gian Luca Grazi, Istituto Nazionale Tumori Regina Elena, Roma; Enrico Gringeri University of Padua, Padova;Guido Griseri, Ospedale San Paolo, Savona;Silvio Guerriero, Belluno.Elio Jovine, Ospedale Maggiore, Bologna;Paolo Magistri, University of Modena and Reggio Emilia; Pietro Maida, Ospedale Villa Betania, Napoli;Marco Massani, Treviso.Pietro Mezzatesta, Casa di Cura La Maddalena, Palermo;Luca Morelli,Pisa.Nadia Russolillo, Ospedale Mauriziano Umberto I, Torino; Giuseppe Navarra, AOU Policlinico G. Martino, Messina;Amilcare Parisi, AO Santa Maria di Terni, Terni;Alberto Patriti, Spoleto.Matteo Ravaioli, Policlinico Sant’Orsola Malpighi, Bologna; Francesca Ratti, IRCCS San Raffaele Hospital, Milano;Raffaele Romito, Novara.Paolo Reggiani, Policlinico di Milano, Milano;Andrea Ruzzenente, University of Verona, Verona; Roberto Santambrogio, AO San Paolo, Milano;Giammauro Berardi, San Camillo Hospital, Rome;Giovanni Sgroi, AO Treviglio-Caravaggio, Treviglio;Abdallah Slim, AO Desio e Vimercate, Vimercate; Marco Spada, OPBG, Roma.Carlo Sposito, University of Milan, Milano;Umberto Tedeschi, Verona.Giuseppe Tisone, Policlinico Tor Vergata; Roma.Guido Torzilli, Istituto Clinico Humanitas, Rozzano; Luigi Veneroni, Rimini.Leonardo Vincenti, AOU Consorziale Policlinico, Bari;Fausto Zamboni, Ospedale Brotzu, Cagliari;Giuseppe Zimmitti, Brescia.

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Authors and Affiliations

  1. Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy

    Giovanni Battista Levi Sandri, Marco Colasanti & Giuseppe Maria Ettorre

  2. Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Milan, Italy

    Luca Aldrighetti

  3. Department of Hepatobiliary Surgery, G.B. Rossi Hospital, University of Verona, Verona, Italy

    Alfredo Guglielmi

  4. Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy

    Umberto Cillo

  5. Department of Surgery, HPB Surgery and Liver Transplantation, University of Milan, Milan, Italy

    Vincenzo Mazzaferro

  6. Department of Oncology, University of Milan, Milan, Italy

    Vincenzo Mazzaferro

  7. Department of Medicine and Surgery, University of Parma, Parma, Italy

    Raffaele Dalla Valle

  8. Surgical and Transplant Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

    Luciano De Carlis

  9. University of Milano-Bicocca, School of Medicine, Milan, Italy

    Luciano De Carlis

  10. Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico—Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), University of Pittsburgh Medical Center (UPMC), 90127, Palermo, Italy

    Salvatore Gruttadauria

  11. Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy

    Fabrizio Di Benedetto

  12. Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy

    Alessandro Ferrero

  13. Department of Surgery and Medical and Surgical Specialties, University of Catania, 95124, Catania, Italy

    Salvatore Gruttadauria

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  1. Giovanni Battista Levi Sandri
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Consortia

I Go MILS Group on HCC

  • Adelmo Antonucci
  • , Giacomo Batignani
  • , Giulio Belli
  • , Andrea Belli
  • , Stefano Berti
  • , Ugo Boggi
  • , Pasquale Bonsignore
  • , Alberto Brolese
  • , Fulvio Calise
  • , Graziano Ceccarelli
  • , Sara Cecconi
  • , Michele Colledan
  • , Andrea Coratti
  • , Giorgio Ercolani
  • , Fabio Ferla
  • , Mauro Filauro
  • , Antonio Floridi
  • , Antonio Frena
  • , Antonio Giuliani
  • , Felice Giuliante
  • , Gian Luca Grazi
  • , Enrico Gringeri
  • , Guido Griseri
  • , Silvio Guerriero
  • , Elio Jovine
  • , Paolo Magistri
  • , Pietro Maida
  • , Marco Massani
  • , Pietro Mezzatesta
  • , Luca Morelli
  • , Nadia Russolillo
  • , Giuseppe Navarra
  • , Amilcare Parisi
  • , Alberto Patriti
  • , Matteo Ravaioli
  • , Francesca Ratti
  • , Raffaele Romito
  • , Paolo Reggiani
  • , Andrea Ruzzenente
  • , Roberto Santambrogio
  • , Giammauro Berardi
  • , Giovanni Sgroi
  • , Abdallah Slim
  • , Marco Spada
  • , Carlo Sposito
  • , Umberto Tedeschi
  • , Giuseppe Tisone
  • , Guido Torzilli
  • , Luigi Veneroni
  • , Leonardo Vincenti
  • , Fausto Zamboni
  •  & Giuseppe Zimmitti

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Correspondence to Giovanni Battista Levi Sandri or Luca Aldrighetti.

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Levi Sandri, G.B., Colasanti, M., Aldrighetti, L. et al. Is minimally invasive liver surgery a reasonable option in recurrent HCC? A snapshot from the I Go MILS registry. Updates Surg 74, 87–96 (2022). https://doi.org/10.1007/s13304-021-01161-w

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