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New prognostic western score predicting survival after curative resection of gastric cancer

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Abstract

The aim of our study was to develop a prognostic score for gastric cancer patients who underwent R0 resection with curative intent, to identify high-risk patients. Three thirty three patients curatively operated for gastric adenocarcinoma were enrolled in the study. To define our prognostic score pre-operative inflammation sieric markers such as neutrophil to lymphocytes ratio, platelet count, platelet to lymphocytes ratio, and other clinical pathological and surgical characteristics of our patients such as albumin preoperative level, CRP sieric level, hystological Lauren’s subtype, tumor location, lymphonodal status were analyzed. Prognostic factors predicting OS were analyzed using Cox proportional hazards models and a prognostic score was built. 5Y-OS was 42% with a median survival of 41 months. The multivariate analysis identified four independent prognostic factors: preoperative albumin level (HR 2.5), preoperative N/L ratio (HR 2.4), Diffuse Lauren histological subtype (HR 1.5) and TNM stage III and IV (HR 1.2). According to the relative risk of each variable we construct a prognostic score and validated it internally. Four risk classes were built and patients were statistically different stratifying according to them. More important the stratification was maintained also when patients were subdivided according to the pathological stage. In summary, we were able to construct a prognostic score that could be easily used in all the clinical contests, being it cheap and prompt. Our results, however, need to be externally validated, by a major center to be introduced into the clinical practice.

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Authors and Affiliations

  1. General and Emergency Surgery, University of Perugia, Via dottori, 06100, Perugia, Italy

    Graziosi Luigina, Marino Elisabetta, Vannoni Maria Cristina & Donini Annibale

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  1. Graziosi Luigina
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  2. Marino Elisabetta
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  3. Vannoni Maria Cristina
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  4. Donini Annibale
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Correspondence to Graziosi Luigina.

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Ethical standards have been respected, according to the Helsinki’s declaration

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All the patients were enrolled according to our Istitution policy previous a written consens form. Data were analyzed anonimously.

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Luigina, G., Elisabetta, M., Cristina, V.M. et al. New prognostic western score predicting survival after curative resection of gastric cancer. Updates Surg 72, 1023–1030 (2020). https://doi.org/10.1007/s13304-020-00835-1

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  • DOI: https://doi.org/10.1007/s13304-020-00835-1

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