Skip to main content

Advertisement

Log in

Lateral retroperitoneoscopic adrenalectomy: advantages and drawbacks

  • Original Article
  • Published:
Updates in Surgery Aims and scope Submit manuscript

Abstract

Lateral retroperitoneoscopic adrenalectomy (LRA) is performed mostly by urologists. It is gaining popularity among general surgeons because of the direct access to the adrenal gland. However, the management of large tumors remains controversial. We report our experience and discuss the advantages and the drawbacks of this approach. Between December 2011 and April 2015, 89 consecutive patients underwent LRA for adrenal tumors. Conversion to open surgery, operative time, blood loss, hospital stay, intra-operative complications, early and late postoperative complications, and mortality were analyzed. The entire group was divided into patients with large tumors (> 5 cm) and patients with small tumors (≤ 5 cm), which were further compared. The conversion rate was 1.1%. The mean operative time was 107.4 ± 27.95 min, the mean blood loss 33.15 ± 25.45 ml. The mean hospital stay was 4.7 ± 2.05 days. Most of the complications were minor. There was zero mortality. Concerning the size of the tumor, we found statistically significant difference in operative time (p = 0.001), hospital stay (p = 0.020), incidence of early postoperative complications (p = 0.049), and conversion rate to open surgery (p = 0.037). LRA is a feasible, effective and safe procedure that offers additional advantages over the standard transabdominal approach because of its direct access to the adrenal gland. However, malignancy, large tumor size, bilateral pathology, and concomitant intra-abdominal pathology may represent a potential setback for this approach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gasman D, Droupy S, Koutani A, Salomon L, Antiphon P, Chassagnon J, Chopin DK, Abbou CC (1998) Laparoscopic adrenalectomy: the retroperitoneal approach. J Urol 159:1816–1820

    CAS  PubMed  Google Scholar 

  2. Ramacciato G, Nigri GR, Petrucciani N, Di Santo V, Piccoli M, Buniva P, Valabrega S, D’Angelo F, Aurello P, Mercantini P, Del Gaudio M, Melotti G (2011) Minimally invasive adrenalectomy: a multicenter comparison of transperitoneal and retroperitoneal approaches. Am Surg 77:409–416

    PubMed  Google Scholar 

  3. Suzuki K, Kageyama S, Hirano Y, Ushiyama T, Rajamahanty S, Fujita K (2001) Comparison of 3 surgical approaches to laparoscopic adrenalectomy: a nonrandomized, background matched analysis. J Urol 166:437–443

    CAS  PubMed  Google Scholar 

  4. Lin Y, Li L, Zhu J, Qiang W, Makiyama K, Kubota Y (2007) Experience of retroperitoneoscopic adrenalectomy in 195 patients with primary aldosteronism. Int J Urol 14:910–913

    PubMed  Google Scholar 

  5. Dickson PV, Jimenez C, Chisholm GB, Kennamer DL, Ng C, Grubbs EG, Evans DB, Lee JE, Perrier ND (2011) Posterior retroperitoneoscopic adrenalectomy: a contemporary American experience. J Am Coll Surg 212:659–665

    PubMed  Google Scholar 

  6. Chen W, Liang Y, Lin W, Fu GQ, Ma ZW (2018) Surgical management of large adrenal tumors: impact of different laparoscopic approaches and resection methods on perioperative and long-term outcomes. BMC Urol 18:31

    PubMed  PubMed Central  Google Scholar 

  7. Pędziwiatr M, Wierdak M, Ostachowski M, Natkaniec M, Białas M, Hubalewska-Dydejczyk A, Matłok M, Major P, Budzyński P, Migaczewski M, Budzyński A (2015) Single center outcomes of laparoscopic transperitoneal lateral adrenalectomy-Lessons learned after 500 cases: a retrospective cohort study. Int J Surg 20:88–94

    PubMed  Google Scholar 

  8. Park HS, Roman SA, Sosa JA (2009) Outcomes from 3144 adrenalectomies in the United States: which matters more, surgeon volume or specialty? Arch Surg 144:1060–1067

    PubMed  Google Scholar 

  9. Gumbs AA, Gagner M (2006) Laparoscopic adrenalectomy. Best Pract Res Clin Endocrinol Metab 20:483–499

    PubMed  Google Scholar 

  10. Assalia A, Gagner M (2004) Laparoscopic adrenalectomy. Br J Surg 91:1259–1274

    CAS  PubMed  Google Scholar 

  11. Berber E, Tellioglu G, Harvey A, Mitchell J, Milas M, Siperstein A (2009) Comparison of laparoscopic transabdominal lateral versus posterior retroperitoneal adrenalectomy. Surgery 146:621–625

    PubMed  Google Scholar 

  12. Lezoche E, Guerrieri M, Feliciotti F, Paganini AM, Perretta S, Baldarelli M, Bonjer J, Miccoli P (2002) Anterior, lateral, and posterior retroperitoneal approaches in endoscopic adrenalectomy. Surg Endosc 16:96–99

    CAS  PubMed  Google Scholar 

  13. Bonjer HJ, Lange JF, Kazemier G, de Herder WW, Steyerberg EW, Bruining HA (1997) Comparison of three techniques for adrenalectomy. Br J Surg 84:679–682

    CAS  PubMed  Google Scholar 

  14. Terachi T, Yoshida O, Matsuda T, Orikasa S, Chiba Y, Takahashi K, Takeda M, Higashihara E, Murai M, Baba S, Fujita K, Suzuki K, Ohshima S, Ono Y, Kumazawa J, Naito S (2000) Complications of laparoscopic and retroperitoneoscopic adrenalectomies in 370 cases in Japan: a multi-institutional study. Biomed Pharmacother 54:211s–214s

    PubMed  Google Scholar 

  15. Naya Y, Nagata M, Ichikawa T, Amakasu M, Omura M, Nishikawa T, Yamaguchi K, Ito H (2002) Laparoscopic adrenalectomy: comparison of transperitoneal and retroperitoneal approaches. BJU Int 90:199–204

    CAS  PubMed  Google Scholar 

  16. Greco F, Hoda MR, Rassweiler J, Fahlenkamp D, Neisius DA, Kutta A, Thüroff JW, Krause A, Strohmaier WL, Bachmann A, Hertle L, Popken G, Deger S, Doehn C, Jocham D, Loch T, Lahme S, Janitzky V, Gilfrich CP, Klotz T, Kopper B, Rebmann U, Kälbe T, Wetterauer U, Leitenberger A, Rassler J, Kawan F, Inferrera A, Wagner S, Fornara P (2011) Laparoscopic adrenalectomy in urological centres—the experience of the German Laparoscopic Working Group. BJU Int 108:1646–1651

    PubMed  Google Scholar 

  17. Castillo O, Cortés O, Kerkebe M, Pinto I, Arellano L, Contreras M (2006) Laparoscopic surgery in the treatment of adrenal pathology: experience with 200 cases. Actas Urol Esp 30:926–932

    CAS  PubMed  Google Scholar 

  18. Kim G, Lomanto D, Lawenko MM, Lopez-Gutierrez J, Lee-Ong A, Iyer SG, Cheah WK, So JB, Tsang CB, Fong YF (2013) Single-port endo-laparoscopic surgery in combined abdominal procedures. Asian J Endosc Surg 6:209–213

    PubMed  Google Scholar 

  19. Constantinides VA, Christakis I, Touska P, Palazzo FF (2012) Systematic review and meta-analysis of retroperitoneoscopic versus laparoscopic adrenalectomy. Br J Surg 99:1639–1648

    CAS  PubMed  Google Scholar 

  20. Tiberio GA, Solaini L, Arru L, Merigo G, Baiocchi GL, Giulini SM (2013) Factors influencing outcomes in laparoscopic adrenal surgery. Langenbecks Arch Surg 398:735–743

    PubMed  Google Scholar 

  21. Conzo G, Tartaglia E, Gambardella C, Esposito D, Sciascia V, Mauriello C, Nunziata A, Siciliano G, Izzo G, Cavallo F, Thomas G, Musella M, Santini L (2016) Minimally invasive approach for adrenal lesions: systematic review of laparoscopic versus retroperitoneoscopic adrenalectomy and assessment of risk factors for complications. Int J Surg Suppl 1:S118–S123

    Google Scholar 

  22. Major P, Matłok M, Pędziwiatr M, Budzyński A (2012) Do we really need routine drainage after laparoscopic adrenalectomy and splenectomy? Wideochir Inne Tech Maloinwazyjne 7:33–39

    PubMed  Google Scholar 

  23. Lombardi CP, Raffaelli M, De Crea C, Sollazzi L, Perilli V, Cazzato MT, Bellantone R (2008) Endoscopic adrenalectomy: is there an optimal operative approach? Results of a single-center case-control study. Surgery 144:1008–1014

    PubMed  Google Scholar 

  24. de La Chapelle A, Deghmani M, Dureuil B (1998) Peritoneal insufflation can be a critical moment in the laparoscopic surgery of pheochromocytoma. Ann Fr Anesth Reanim 17:1184–1185

    Google Scholar 

  25. Fernández-Cruz L, Saenz A, Benarroch G, Astudillo E, Taura P, Sabater L (1996) Laparoscopic unilateral and bilateral adrenalectomy for Cushing’s syndrome. Transperitoneal and retroperitoneal approaches. Ann Surg 224:727–734

    PubMed  PubMed Central  Google Scholar 

  26. Gockel I, Vetter G, Heintz A, Junginger T (2005) Endoscopic adrenalectomy for pheochromocytoma: difference between the transperitoneal and retroperitoneal approaches in terms of the operative course. Surg Endosc 19:1086–1092

    CAS  PubMed  Google Scholar 

  27. Gockel I, Heintz A, Kentner R, Werner C, Junginger T (2005) Changing pattern of the intraoperative blood pressure during endoscopic adrenalectomy in patients with Conn’s syndrome. Surg Endosc 19:1491–1497

    CAS  PubMed  Google Scholar 

  28. Boscaro M, Sonino N, Scarda A, Barzon L, Fallo F, Sartori MT, Patrassi GM, Girolami A (2002) Anticoagulant prophylaxis markedly reduces thromboembolic complications in Cushing’s syndrome. J Clin Endocrinol Metab 87:3662–3666

    CAS  PubMed  Google Scholar 

  29. Nocca D, Aggarwal R, Mathieu A, Blanc PM, Deneve E, Salsano V, Figueira G, Sanders G, Domergue J, Millat B, Fabre PR (2007) Laparoscopic surgery and corticoadrenalomas. Surg Endosc 21:1373–1376

    CAS  PubMed  Google Scholar 

  30. Siperstein AE, Berber E, Engle KL, Duh QY, Clark OH (2000) Laparoscopic posterior adrenalectomy: technical considerations. Arch Surg 135:967–971

    CAS  PubMed  Google Scholar 

  31. Rubinstein M, Gill IS, Aron M, Kilciler M, Meraney AM, Finelli A, Moinzadeh A, Ukimura O, Desai MM, Kaouk J, Bravo E (2005) Prospective, randomized comparison of transperitoneal versus retroperitoneal laparoscopic adrenalectomy. J Urol 174:442–445

    PubMed  Google Scholar 

  32. Cabalag MS, Mann GB, Gorelik A, Miller JA (2014) Comparison of outcomes after laparoscopic versus posterior retroperitoneoscopic adrenalectomy: a pilot study. Surg Laparosc Endosc Percutan Tech 24:62–66

    PubMed  Google Scholar 

  33. Callender GG, Kennamer DL, Grubbs EG, Lee JE, Evans DB, Perrier ND (2009) Posterior retroperitoneoscopic adrenalectomy. Adv Surg 43:147–157

    PubMed  Google Scholar 

  34. Guerrieri M, Campagnacci R, De Sanctis A, Baldarelli M, Coletta M, Perretta S (2008) The learning curve in laparoscopic adrenalectomy. J Endocrinol Invest 31:531–536

    CAS  PubMed  Google Scholar 

  35. Bakkar S, Materazzi G, Fregoli L, Papini P, Miccoli P (2017) Posterior retroperitonoscopic adrenalectomy; a back door access with an unusually rapid learning curve. Updates Surg 69:235–239

    PubMed  Google Scholar 

  36. Kwan TL, Lam CM, Yuen AW, Lo CY (2007) Adrenalectomy in Hong Kong: a critical review of adoption of laparoscopic approach. Am J Surg 194:153–158

    PubMed  Google Scholar 

  37. Walz MK, Alesina PF, Wenger FA, Deligiannis A, Szuczik E, Petersenn S, Ommer A, Groeben H, Peitgen K, Janssen OE, Philipp T, Neumann HP, Schmid KW, Mann K (2006) Posterior retroperitoneoscopic adrenalectomy–results of 560 procedures in 520 patients. Surgery 140:943–948

    PubMed  Google Scholar 

  38. Zhang X, Fu B, Lang B, Zhang J, Xu K, Li HZ, Ma X, Zheng T (2007) Technique of anatomical retroperitoneoscopic adrenalectomy with report of 800 cases. J Urol 177:1254–1257

    PubMed  Google Scholar 

  39. Kiriakopoulos A, Economopoulos KP, Poulios E, Linos D (2011) Impact of posterior retroperitoneoscopic adrenalectomy in a tertiary care center: a paradigm shift. Surg Endosc 25:3584–3589

    PubMed  Google Scholar 

  40. Lan BY, Taskin HE, Aksoy E, Birsen O, Dural C, Mitchell J, Siperstein A, Berber E (2015) Factors affecting the surgical approach and timing of bilateral adrenalectomy. Surg Endosc 29:1741–1745

    PubMed  Google Scholar 

  41. Agha A, von Breitenbuch P, Gahli N, Piso P, Schlitt HJ (2008) Retroperitoneoscopic adrenalectomy: lateral versus dorsal approach. J Surg Oncol 97:90–93

    PubMed  Google Scholar 

  42. Karanikola E, Tsigris C, Kontzoglou K, Nikiteas N (2010) Laparoscopic adrenalectomy: where do we stand now? Tohoku J Exp Med 220:259–265

    PubMed  Google Scholar 

  43. Castillo OA, Vitagliano G, Secin FP, Kerkebe M, Arellano L (2008) Laparoscopic adrenalectomy for adrenal masses: does size matter? Urology 71:1138–1141

    PubMed  Google Scholar 

  44. Sharma R, Ganpule A, Veeramani M, Sabnis RB, Desai M (2009) Laparoscopic management of adrenal lesions larger than 5 cm in diameter. Urol J 6:254–259

    PubMed  Google Scholar 

  45. Agha A, Iesalnieks I, Hornung M, Phillip W, Schreyer A, Jung M, Schlitt HJ (2014) Laparoscopic trans- and retroperitoneal adrenal surgery for large tumors. J Minim Access Surg 10:57–61

    PubMed  PubMed Central  Google Scholar 

  46. Chen W, Li F, Chen D, Zhu Y, He C, Du Y, Tan W (2013) Retroperitoneal versus transperitoneal laparoscopic adrenalectomy in adrenal tumor: a meta-analysis. Surg Laparosc Endosc Percutan Tech 23:121–127

    PubMed  Google Scholar 

  47. Xu T, Xia L, Wang X, Zhang X, Zhong S, Qin L, Zhang X, Zhu Y, Shen Z (2015) Effectiveness of partial adrenalectomy for concomitant hypertension in patients with nonfunctional adrenal adenoma. Int Urol Nephrol 47:59–67

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Konstantin Grozdev.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study (retrospective analysis), formal consent is not required. The study was approved by the Institutional Review Board of Alexandrovska University Hospital, Sofia.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grozdev, K., Khayat, N., Shumarova, S. et al. Lateral retroperitoneoscopic adrenalectomy: advantages and drawbacks. Updates Surg 72, 1151–1157 (2020). https://doi.org/10.1007/s13304-020-00741-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13304-020-00741-6

Keywords

Navigation