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Myoxinol ointment for the treatment of acute fissure

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Abstract

Myoxinol is a complex of oligopeptides obtained from the seeds of Hibiscus esculentus used in cosmetic as natural alternative to botulin toxin. The aim of the study was to evaluate the safety and effectiveness of local myoxinol for the treatment of acute anal fissure. All the consecutive patients with acute fissure treated from January to June 2014 underwent 30 days of topical treatment (twice/day) with a mioxinol based ointment. Pain, symptomatic relief, fissure healing and re-epithelization, 1-year recurrence rate, subjective satisfaction and need for further treatments were evaluated. During the study period 157 patients were eligible for data analysis (91 males: 58%; mean age 38 years: range 17–83). Median anal pain score was 7.1 pre-treatment and 1.7 and 0.9 after 30 days and 12 months from treatment, respectively (p: 0.0001). After the treatment period complete healing was achieved in 103 patients (65.5%), relevant improvement in 31 (20%) and no improvement in 21 patients (13.5%). Overall efficacy rate was 85.5%. A significant difference was reported considering patients with pre-treatment VAS between 1–5 and 6–10 (p: 0.004). Twenty-nine patients (18.5%) required further treatments. Hydrolyzed Hibiscus esculentus extract was proven to be an effective and well-tolerated topical treatment for acute fissure, with a high healing rate, a significant reduction of pain and a low 1-year recurrence rate.

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Authors and Affiliations

  1. General, Emergency and Mini-invasive Surgery, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy

    J. Martellucci

  2. General Surgery Unit, Prato Hospital, Prato, Italy

    G. Rossi

  3. General Surgery Unit, Pescia Hospital, Pescia, Italy

    I. Corsale

  4. General Surgery Unit, Borgo San Lorenzo Hospital, Borgo San Lorenzo, Italy

    P. Carrieri

  5. General Surgery Unit, Massa Hospital, Massa, Italy

    M. D’Elia

  6. Proctological and Perineal Surgical Unit, Cisanello University Hospital, Pisa, Italy

    I. Giani

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  1. J. Martellucci
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  2. G. Rossi
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  3. I. Corsale
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  4. P. Carrieri
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  5. M. D’Elia
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  6. I. Giani
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Correspondence to J. Martellucci.

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The authors declare that they have no conflict of interest to be disclosed.

Research involving human participants and/or animals

All procedures performed in the present study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Martellucci, J., Rossi, G., Corsale, I. et al. Myoxinol ointment for the treatment of acute fissure. Updates Surg 69, 499–503 (2017). https://doi.org/10.1007/s13304-017-0450-z

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  • DOI: https://doi.org/10.1007/s13304-017-0450-z

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