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Breast cancer in young women: an overview

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Abstract

Despite dramatic advances in cancer research setting, breast cancer remains a major health problem and represents currently a top biomedical research priority. Worldwide, breast cancer is the most common cancer affecting women, and its incidence and mortality rates are expected to increase significantly the next years. Recently the researchers’ interest has been attracted by breast cancer arising in young women. Current evidence suggests that in women aged <45 years, breast cancer is unquestionably the leading cause of cancer-related deaths. This type of cancer seems to be highly heterogeneous and has potentially aggressive and complex biological features. However, management strategies, recommendations and options are not age based and the ‘complex’ biology of this type of cancer remains uncertain and unexplored. In this review, we summarize the latest scientific information on breast cancer arising in young women highlighting the heterogeneity and the complex nature of this type of cancer.

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References

  1. DeSantis C, Ma J, Bryan L, Jemal A (2014) Breast cancer statistics, 2013. CA Cancer J Clin 64(1):52–62

    Article  PubMed  Google Scholar 

  2. DeSantis C, Howlader N, Cronin KA, Jemal A (2011) Breast cancer incidence rates in U.S. women are no longer declining. Cancer Epidemiol Bio-markers Prev 20:733–749

    Article  Google Scholar 

  3. Greaney ML, Sprunck-Harrild K, Ruddy KJ et al (2015) Study protocol for Young & Strong: a cluster randomized design to increase attention to unique issues faced by young women with newly diagnosed breast cancer. BMC Public Health 31(15):37

    Article  Google Scholar 

  4. Villarreal-Garza C, Aguila C, Magallanes-Hoyos MC, Mohar A et al (2013) Breast cancer in young women in Latin America: an unmet, growing burden. Oncologist 18(Suppl):26–34. doi:10.1634/theoncologist.18-S2-26

    Article  PubMed  Google Scholar 

  5. Schmidt C (2015) Immunology: another shot at cancer. Nature 527(7578):S105–S107

    Article  CAS  PubMed  Google Scholar 

  6. Adams JU (2015) Genetics: big hopes for big data. Nature 527(7578):S108–S109

    Article  CAS  PubMed  Google Scholar 

  7. Eisenstein M (2015) Medicine: eyes on the target. Nature 527(7578):S110–S112

    Article  CAS  PubMed  Google Scholar 

  8. Reyna C, Lee MC (2014) Breast cancer in young women: special considerations in multidisciplinary care. J Multidiscip Healthc 29(7):419–429

    Google Scholar 

  9. Kroman N, Jensen MB, Wohlfahrt J, Mouridsen HT, Andersen PK, Melbye M (2000) Factors influencing the effect of age on prognosis in breast cancer: population based study. BMJ 320:474–478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Fredholm H, Eaker S, Frisell J et al (2009) Breast cancer in young women: poor survival despite intensive treatment. PLoS One 4(11):e7695

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hoag H (2015) Molecular biology: marked progress. Nature 527(7578):S114–S115

    Article  CAS  PubMed  Google Scholar 

  12. Lianos GD, Vlachos K, Zoras O (2014) Potential of antibody-drug conjugates and novel therapeutics in breast cancer management. Onco Targets Ther 24(7):491–500

    Google Scholar 

  13. Lianos GD, Roukos DH (2014) From linear ‘dogma’ and trastuzumab-emtansine to future transcriptional circuitry-based drug discovery for breast cancer. Future Oncol 10(2):145–148

    Article  CAS  PubMed  Google Scholar 

  14. Lee HB, Han W (2014) Unique features of young age breast cancer and its management. J Breast Cancer 17(4):301–307

    Article  PubMed  PubMed Central  Google Scholar 

  15. Gabriel CA, Domchek SM (2010) Breast cancer in young women. Breast Cancer Res 12:212

    Article  PubMed  PubMed Central  Google Scholar 

  16. Anders CK, Hsu DS, Broadwater G et al (2008) Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 26:3324–3330

    Article  PubMed  Google Scholar 

  17. Jankowsk M (2013) Sexual functioning in young women in the context of breast cancer treatment. Rep Pract Oncol Radiother 18(4):193–200

    Article  Google Scholar 

  18. Han W, Kim SW, Park IA, Kang D, Kim SW, Youn YK et al (2004) Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer 4:82

    Article  PubMed  PubMed Central  Google Scholar 

  19. Anders CK, Fan C, Parker JS, Carey LA, Blackwell KL, Klauber-De-More N et al (2011) Breast carcinomas arising at a young age: unique biology or a surrogate for aggressive intrinsic subtypes? J Clin Oncol 29:e18–e20

    Article  PubMed  Google Scholar 

  20. Chung M, Chang HR, Bland KI, Wanebo HJ (1996) Younger women with breast carcinoma have a poorer prognosis than older women. Cancer 77:97–103

    Article  CAS  PubMed  Google Scholar 

  21. Kim HJ, Han W, Yi OV, Shin HC, Ahn SK, Koh BS et al (2011) Young age is associated with ipsilateral breast tumor recurrence after breast conserving surgery and radiation therapy in patients with HER2-positive/ER-negative subtype. Breast Cancer Res Treat 130:499–505

    Article  PubMed  Google Scholar 

  22. Vitale SG, Valenti G, Gulino FA, Cignini P, Biondi A (2016) Surgical treatment of high stage endometrial cancer: current perspectives. Updates Surg 68(2):149–154

    Article  PubMed  Google Scholar 

  23. Rossetti D, Vitale SG, Gulino FA, Cignini P, Rapisarda AMC, Biondi A, Frigerio L (2016) Concomitant chemoradiation treatment in selected stage I endometrioid endometrial cancers. Eur J Gynaecol Oncol 37(5):657–661

    Google Scholar 

  24. Woodson AH, Profato JL, Muse KI, Litton JK et al (2013) Breast cancer in the young: role of the geneticist. J Thorac Dis 5(Suppl 1):S19–S26

    PubMed  PubMed Central  Google Scholar 

  25. Desmedt C, Yates L, Kulka J et al (2016) Catalog of genetic progression of human cancers: breast cancer. Cancer Metastasis Rev 35(1):49–62

    CAS  PubMed  Google Scholar 

  26. Weisman PS, Ng CK, Brogi E et al (2016) Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology. Mod Pathol 29(5):476–488

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Azim HA Jr, Partridge AH (2014) Biology of breast cancer in young women. Breast Cancer Res 16(4):427

    Article  PubMed  PubMed Central  Google Scholar 

  28. Stephens PJ, Tarpey PS, Davies H et al (2012) The landscape of cancer genes and mutational processes in breast cancer. Nature 486(7403):400–404

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Azim HA Jr, Brohee S, Peccatori FA et al (2014) Biology of breast cancer during pregnancy using genomic profiling. Endocr Relat Cancer 21:545–554

    Article  CAS  PubMed  Google Scholar 

  30. Shuen AY, Foulkes WD (2011) Inherited mutations in breast cancer genes—risk and response. J Mamm Gland Biol Neoplasia 16:3–15

    Article  Google Scholar 

  31. Huzarski T, Byrski T, Gronwald J et al (2013) Ten-year survival in patients with BRCA1-negative and BRCA1-positive breast cancer. J Clin Oncol 31:3191–3196

    Article  PubMed  Google Scholar 

  32. Weischer M, Nordestgaard BG, Pharoah P et al (2012) CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol 30:4308–4316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Lianos GD, Zoras O, Roukos DH (2013) Beyond BRCA1/2: polygenic, ‘polyfunctional’ molecular circuitry model to predict breast cancer risk. Biomark Med 7(5):675–678

    Article  CAS  PubMed  Google Scholar 

  34. Copson E, Eccles B, Maishman T, Gerty S, Stanton L, Cutress RI, Altman DG, Durcan L, Simmonds P, Lawrence G, Jones L, Bliss J, Eccles D (2013) POSH Study Steering Group: prospective observational study of breast cancer treatment outcomes for UK women aged 18–40 years at diagnosis: the POSH study. J Natl Cancer Inst 105:978–988

    Article  CAS  PubMed  Google Scholar 

  35. Collins LC, Marotti JD, Gelber S, Cole K, Ruddy K, Kereakoglow S, Brachtel EF, Schapira L, Come SE, Winer EP, Partridge AH (2012) Pathologic features and molecular phenotype by patient age in a large cohort of young women with breast cancer. Breast Cancer Res Treat 131:1061–1066

    Article  CAS  PubMed  Google Scholar 

  36. Gnerlich JL, Deshpande AD, Jeffe DB, Sweet A, White N, Margenthaler JA (2009) Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease. J Am Coll Surg 208:341–347

    Article  PubMed  PubMed Central  Google Scholar 

  37. Keegan TH, DeRouen MC, Press DJ, Kurian AW, Clarke CA (2012) Occurrence of breast cancer subtypes in adolescent and young adult women. Breast Cancer Res 14:R55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Azim HA Jr, Nguyen B, Brohée S et al (2015) Genomic aberrations in young and elderly breast cancer patients. BMC Med 15(13):266

    Article  Google Scholar 

  39. Azim H, Azim HA Jr (2013) Targeting RANKL in breast cancer: bone metastasis and beyond. Expert Rev Anticancer Ther 13:195–201

    Article  CAS  PubMed  Google Scholar 

  40. Ribnikar D, Ribeiro JM, Pinto D et al (2015) Breast cancer under age 40: a different approach. Curr Treat Options Oncol 16(4):16

    Article  CAS  PubMed  Google Scholar 

  41. Ademuyiwa FO, Cyr A, Ivanovich J, Thomas MA (2015) Managing breast cancer in younger women: challenges and solutions. Breast Cancer (Dove Med Press) 21(8):1–12

    Google Scholar 

  42. Bellia A, Vitale SG, Laganà AS et al (2016) Feasibility and surgical outcomes of conventional and robot-assisted laparoscopy for early-stage ovarian cancer: a retrospective, multicenter analysis. Arch Gynecol Obstet 294(3):615–622

    Article  PubMed  Google Scholar 

  43. Vitale SG, Valenti G, Biondi A, Rossetti D, Frigerio L (2015) Recent trends in surgical and reconstructive management of vulvar cancer: review of literature. Updates Surg 67(4):367–371

    Article  PubMed  Google Scholar 

  44. Freedman RA, Partridge AH (2013) Management of breast cancer in very young women. Breast 22(Suppl 2):S176–S179. doi:10.1016/j.breast.2013.07.034

    Article  PubMed  Google Scholar 

  45. Ferzoco RM, Ruddy KJ (2015) Unique aspects of caring for young breast cancer patients. Curr Oncol Rep. 17(2):1. doi:10.1007/s11912-014-0425-x

    Article  PubMed  Google Scholar 

  46. Verigos J, Magklara A (2015) Revealing the complexity of breast cancer by next generation sequencing. Cancers (Basel) 7(4):2183–2200

    Article  Google Scholar 

  47. Martelotto LG, Ng CK, Piscuoglio S, Weigelt B, Reis-Filho JS (2014) Breast cancer intra-tumor heterogeneity. Breast Cancer Res 16(3):210

    Article  PubMed  PubMed Central  Google Scholar 

  48. Desmedt C, Voet T, Sotiriou C, Campbell PJ (2012) Next-generation sequencing in breast cancer: first take home messages. Curr Opin Oncol 24(6):597–604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Rosa M (2015) Advances in the molecular analysis of breast cancer: pathway toward personalized medicine. Cancer Control 22(2):211–219

    Article  PubMed  Google Scholar 

  50. Roukos DH (2010) Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care. Expert Rev Mol Diagn 10(1):33–48

    Article  CAS  PubMed  Google Scholar 

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    Authors and Affiliations

    1. Department of Surgery, School of Medicine, University of Ioannina, Ioannina, Greece

      Zoi Anastasiadi, Georgios D. Lianos, Eleftheria Ignatiadou, Haralampos V. Harissis & Michail Mitsis

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    1. Zoi Anastasiadi
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    2. Georgios D. Lianos
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    3. Eleftheria Ignatiadou
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    4. Haralampos V. Harissis
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    5. Michail Mitsis
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    Correspondence to Georgios D. Lianos.

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    Z. Anastasiadi and G. D. Lianos contributed equally to this article.

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    Anastasiadi, Z., Lianos, G.D., Ignatiadou, E. et al. Breast cancer in young women: an overview. Updates Surg 69, 313–317 (2017). https://doi.org/10.1007/s13304-017-0424-1

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    • DOI: https://doi.org/10.1007/s13304-017-0424-1

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