Skip to main content

Nutritional aspects in patient undergoing liver resection

Abstract

In the past two decades, hepatic surgery has achieved important technical breakthroughs resulting in a drastic reduction of the onset of complications and in an improved post-resective survival. Pre-operative nutritional status is one of the key points for the success of a liver resection. Modern surgical achievement such as the development of living-related liver donation, and the possibility to perform more laparoscopic liver resection gave us the opportunity to extend post-operative protocol focused on early intestinal feeding to tumor patients. The aims of this review were to report the current status of the knowledge regarding nutritional aspects in liver resection patients.

This is a preview of subscription content, access via your institution.

References

  1. Lortat-Jacob JL, Robert HG (1952) Hepatectomy droite rélée. Pres. Méd 60:549

    CAS  Google Scholar 

  2. Clavien PA, Petrowsky H, DeOliveira ML, Graf R (2007) Strategies for safer liver surgery and partial liver transplantation. N Engl J Med 356(15):1545–1559

    PubMed  Article  Google Scholar 

  3. Farges O, Belghiti J, Kianmanesh R et al (2003) Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 237(2):208–217

    PubMed  Google Scholar 

  4. Abdalla EK, Barnett CC, Doherty D, Curley SA, Vauthey JN (2002) Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization. Arch Surg 137(6):675–680

    PubMed  Article  Google Scholar 

  5. Gruttadauria S, Saint Georges Chaumet M, Pagano D et al (2011) Impact of blood transfusion on early outcome of liver resection for colorectal hepatic metastases. J Surg Oncol 103(2):140–147

    PubMed  Article  Google Scholar 

  6. Gruttadauria S, Pagano D, Petridis I et al (2010) Hepatitis C virus infection in a living-related liver donor. Am J Transplant 10(1):191

    PubMed  Article  CAS  Google Scholar 

  7. Kishi Y, Abdalla EK, Chun YS et al (2009) Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Ann Surg 250(4):540–548

    PubMed  Google Scholar 

  8. Dahm F, Georgiev P, Clavien PA (2005) Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 5(11):2605–2610

    PubMed  Article  Google Scholar 

  9. Hassanain M, Schricker T, Metrakos P et al (2008) Hepatic protection by perioperative metabolic support? Nutrition 24(11–12):1217–1219 (Epub 2008 Jun 30)

  10. Sungurtekin H, Sungurtekin U, Balci C et al (2004) The influence of nutritional status on complications after major intraabdominal surgery. J Am Coll Nutr 23(3):227–232

    PubMed  Google Scholar 

  11. Braga M, Ljungqvist O, Soeters P et al (2009) ESPEN Guidelines on Parenteral Nutrition: surgery. Clin Nutr 28(4):378–386 (Epub 2009 May 21)

    Google Scholar 

  12. van den Broek MA, Olde Damink SW, Dejong CH et al (2008) Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liver Int. 28(6):767–780

    PubMed  Article  Google Scholar 

  13. Olthoff KM. (2003) Hepatic regeneration in living donor liver transplantation. Liver Transpl 9(10 Suppl 2):S35–S41

    Google Scholar 

  14. Lesurtel M, Graf R, Aleil B, Walther DJ et al (2006) Platelet-derived serotonin mediates liver regeneration. Science 312(5770):104–107

    PubMed  Article  CAS  Google Scholar 

  15. Murata S, Ohkohchi N, Matsuo R et al (2007) Platelets promote liver regeneration in early period after hepatectomy in mice. World J Surg 31(4):808–816

    PubMed  Article  Google Scholar 

  16. Clavien PA, Graf R (2009) Liver regeneration and platelets. Br J Surg 96(9):965–966

    PubMed  Article  CAS  Google Scholar 

  17. Sanchez AJ, Aranda-Michel J (2006) Nutrition for the liver transplant patient. Liver Transpl 12(9):1310–1316

    PubMed  Article  Google Scholar 

  18. Vitale A, Saracino E, Boccagni P et al (2009) Validation of the BCLC prognostic system in surgical hepatocellular cancer patients. Transpl Proc 41(4):1260–1263

    Article  CAS  Google Scholar 

  19. Richter B, Schmandra TC, Golling M, Bechstein WO (2006) Nutritional support after open liver resection: a systematic review. Dig Surg 23(3):139–145

    PubMed  Article  CAS  Google Scholar 

  20. Shirabe K, Matsumata T, Shimada M, Takenaka K, Kawahara N, Yamamoto K, Nishizaki T, Sugimachi KA (1997) comparison of parenteral hyperalimentation and early enteral feeding regarding systemic immunity after major hepatic resection—the results of a randomized prospective study. Hepatogastroenterology 44(13):205–209

    PubMed  CAS  Google Scholar 

  21. Mochizuki H, Togo S, Tanaka K, Endo I, Shimada H (2000) Early enteral nutrition after hepatectomy to prevent postoperative infection. Hepatogastroenterology 47(35):1407–1410

    PubMed  CAS  Google Scholar 

  22. Hu QG, Zheng QC (2003) The influence of Enteral Nutrition in postoperative patients with poor liver function. World J Gastroenterol 9(4):843–846

    PubMed  CAS  Google Scholar 

  23. Nishizaki T, Takenaka K, Yanaga K, Shimada M, Shirabe K, Matsumata T, Sugimachi K (1996) Nutritional support after hepatic resection: a randomized prospective study. Hepatogastroenterology 43(9):608–613

    PubMed  CAS  Google Scholar 

  24. Fan ST, Lo CM, Lai EC, Chu KM, Liu CL, Wong J (1994) Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma. N Engl J Med 331(23):1547–1552

    PubMed  Article  CAS  Google Scholar 

  25. Usami M, Miyoshi M, Kanbara Y, Aoyama M, Sakaki H, Shuno K, Hirata K, Takahashi M, Ueno K, Tabata S, Asahara T, Nomoto K (2011) Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. JPEN J Parenter Enteral Nutr 35(3):317–328

    PubMed  Article  Google Scholar 

  26. Holecek M (2010) Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition 26(5):482–490 (Epub 2010 Jan 13)

    Google Scholar 

  27. Lautz HU, Selberg O, Körber J et al (1992) Protein-calorie malnutrition in liver cirrhosis. Clin Investig 70(6):478–486

    PubMed  Article  CAS  Google Scholar 

  28. Read JA, Choy ST, Beale PJ, Clarke SJ (2006) Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival. Nutr Cancer 55(1):78–85

    PubMed  Article  CAS  Google Scholar 

  29. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP et al (2002) Improvement in perioperative outcome after hepatic resection: analysis of 1, 803 consecutive cases over the past decade. Ann Surg 236(4):397–406 (discussion 406–407)

    PubMed  Article  Google Scholar 

  30. Imamura H, Seyama Y, Kokudo N et al (2003) One thousand fifty-six hepatectomies without mortality in 8 years. Arch Surg 138(11):1198–1206 (discussion 1206)

    PubMed  Article  Google Scholar 

  31. Kooby DA, Stockman J, Ben-Porat L et al (2003) Influence of transfusions on perioperative and long-term outcome in patients following hepatic resection for colorectal metastases. Ann Surg 237(6):860–869 (discussion 869–870)

    PubMed  Google Scholar 

  32. Plauth M, Cabré E, Campillo B et al (2009) ESPEN Guidelines on Parenteral Nutrition: hepatology. Clin Nutr 28(4):436–444 (Epub 2009 Jun 11)

    Google Scholar 

  33. Gruttadauria S, Marsh JW, Cintorino D et al (2007) Adult to adult living-related liver transplant: report on an initial experience in Italy. Dig Liver Dis 39(4):342–350 (Epub 2007 Mar 6)

    Google Scholar 

  34. Gruttadauria S, Marsh JW, Vizzini GB et al (2008) Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation. World J Gastroenterol 14(20):3159–3164

    PubMed  Article  Google Scholar 

  35. Azoulay D, Bhangui P, Andreani P et al (2011) Short- and long-term donor morbidity in right lobe living donor liver transplantation: 91 consecutive cases in a European Center. Am J Transplant 11(1):101–110

    PubMed  Article  CAS  Google Scholar 

  36. Heffron TG, Gruttadauria S, Campi O, Martin J. Cavanna Surgical innovations in pediatric liver transplantation: reduced-size, split and living-related transplantation. Probl Gen Surg 15(3):104–111

  37. Couinaud C (1989) Surgical anatomy of the liver revisited. Couinaud, Paris

    Google Scholar 

  38. Nitta H, Sasaki A, Fujita T et al (2010) Laparoscopy-assisted major liver resections employing a hanging technique: the original procedure. Ann Surg 251(3):450–453

    Google Scholar 

Download references

Conflict of interest

None

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Salvatore Gruttadauria.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ciuni, R., Biondi, A., Grosso, G. et al. Nutritional aspects in patient undergoing liver resection. Updates Surg 63, 249–252 (2011). https://doi.org/10.1007/s13304-011-0121-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13304-011-0121-4

Keywords

  • Nutrition
  • Metabolism
  • Liver resection
  • Transplantation