Fig. 1

Different patterns of glycemic variability (GV) in two patients with same hemoglobin A1C (HbA1c). 15-day glucose traces of two patients who had identical HbA1c of 8.0% but different degrees of GV. High GV in patient 1 was reflected by numerous episodes of both hypo- and hyperglycemia (a), whereas low GV in subject 2 resulted in no such episodes (b). Patient 1 (a) had visibly higher glucose fluctuations than patient 2 (b) that resulted in seven episodes of moderate hypoglycemia (≤ 50 mg/dL) and eight episodes of moderate hyperglycemia (≥ 350 mg/dL)