Sodium-Glucose Co-Transporter 2 Inhibitors and Fracture Risk

Table 1 Major observational studies that showed an association between type 2 diabetes mellitus (T2DM) and risk of fractures

References	n	Major findings	Comments
[11]	6655	Patients with T2DM had increased nonvertebral fracture risk than subjects without T2DM (hazard ratio 1.33, 95% confidence interval 1.00–1.77)	Patients with T2DM had higher bone mineral density than subjects without T2DM The increased fracture risk was present only in treated patients with T2DM and not in newly diagnosed patients
[12]	996	T2DM was an independent risk factor for prevalent vertebral fracture	Bone mineral density was not associated with the presence of vertebral fracture in patients with T2DM