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History of myocardial infarction
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History of myocardial infarction >2 months prior to informed consent
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Coding of a myocardial infarction or other definite indicator of a myocardial infarction
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Coronary artery disease
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Evidence of multi-vessel coronary artery disease, i.e. in ≥2 major coronary arteries or the left main coronary artery, documented by any of the following:
Presence of significant stenosis: ≥50% luminal narrowing during angiography (coronary or multi-slice computed tomography)
Previous revascularisation (percutaneous transluminal coronary angioplasty ± stent or coronary artery bypass graft >2 months prior to consent
The combination of revascularisation in one major coronary artery and significant stenosis (≥50% luminal narrowing) in another major coronary artery
Evidence of single-vessel coronary artery disease, ≥50% luminal narrowing during angiography (coronary or multi-slice computed tomography) not subsequently successfully re-vascularised, with at least 1 of the following:
A positive non-invasive stress test for ischaemia
Hospital discharge for unstable angina ≤12 months prior to consent
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Evidence of coronary artery disease documented by any of the following:
Coding of double coronary artery disease
Previous revascularisation (percutaneous transluminal coronary angioplasty ± stent or coronary artery bypass graft) of the coronary arteries
NB. Coding of the precise percutaneous intervention performed in primary care is limited. Usually only a high level code is included to indicate the procedure has been undertaken. This coronary artery disease code search is therefore likely to slightly overestimate the number of people who meet the trial criteria
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Unstable angina
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Unstable angina >2 months prior to consent with evidence of single- or multi-vessel coronary artery disease
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Coding of unstable angina or code which indicates poor angina control
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History of stroke
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History of stroke (ischaemic or haemorrhagic) >2 months prior to consent
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Coding of stroke (ischemic or haemorrhagic)
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Peripheral artery disease
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Occlusive peripheral artery disease documented by any of the following:
Limb angioplasty, stenting or bypass surgery
Limb or foot amputation due to circulatory insufficiency
Evidence of significant peripheral artery stenosis (>50% on angiography, or >50% or haemodynamically significant via non-invasive methods) in 1 limb
Ankle brachial index <0.9 in ≥1 ankle
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Coding of peripheral artery disease documented by any of the following:
Limb angioplasty, stenting or bypass surgery
Limb or foot amputation
Coding of peripheral arterial disease of the lower limb(s) including claudication, and peripheral gangrene
A recorded ankle brachial index <0.9
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