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Tumor Biology

, Volume 37, Issue 12, pp 16305–16315 | Cite as

Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation

  • Zhipeng Lin
  • Baoying Hu
  • Wenkai Ni
  • Xiaofei Mao
  • Huiling Zhou
  • Jiale Lv
  • Bihui Yin
  • Zhongyi Shen
  • Miaomiao Wu
  • Wensen Ding
  • Mingbing Xiao
  • Runzhou Ni
Original Article

Abstract

BCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocellular carcinoma (HCC) remains to be determined. Herein, we demonstrated that BCCIP was downregulated in clinical HCC tissues; its level was inversely correlated with multiple clinicopathological factors, such as tumor grade, tumor size, and Ki67 expression. Cox regression analysis of tumor samples revealed that BCCIP expression status was an independent prognostic factor for HCC patients’ poor survival. Our study also indicated that BCCIP shutdown reduces p21 expression and accelerates G1 to S progression of LO2 hepatocytes significantly. Moreover, there is an interaction between BCCIP and p53 in hepatic L02 cells, and the downregulation of p21 expression by BCCIP is in a p53-dependent way. These findings revealed that BCCIP may play a significant role for the determination of HCC progression through its role in regulating cell growth. Thus, our results suggest that BCCIP is of potential interest for prognostic marker and therapeutic target of HCC.

Keywords

BCCIP Hepatocellular carcinoma p53 Prognosis Cell proliferation 

Notes

Compliance with ethical standards

Funding

This study was funded by the following:

1. Natural Youth Foundation of China (grant number 81502072)

2. Natural Youth Foundation of China (grant number 81401985)

3. National Natural Science Foundation of China (grant number 81472272)

4. The Administration of Science and Technology of Nantong (grant number MS22015062)

Conflict of interest

None

Supplementary material

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ESM 1

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High resolution image (TIFF 285 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Zhipeng Lin
    • 1
  • Baoying Hu
    • 2
  • Wenkai Ni
    • 1
  • Xiaofei Mao
    • 3
  • Huiling Zhou
    • 4
  • Jiale Lv
    • 1
  • Bihui Yin
    • 5
  • Zhongyi Shen
    • 1
  • Miaomiao Wu
    • 1
  • Wensen Ding
    • 6
  • Mingbing Xiao
    • 1
  • Runzhou Ni
    • 1
  1. 1.Department of GastroenterologyAffiliated Hospital of Nantong UniversityNantongChina
  2. 2.Basic Medical Research Centre, Medical CollegeNantong UniversityNantongChina
  3. 3.Department of StomatologyThe First Affiliated Hospital of Dalian Medical UniversityDalianChina
  4. 4.Key Laboratory of NeuroregenerationNantong UniversityNantongChina
  5. 5.Department of Hepatic OncologyNantong Tumor HospitalNantongChina
  6. 6.Department of NeurologyAffiliated Hospital of Nantong UniversityNantongChina

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