Tumor Biology

, Volume 37, Issue 12, pp 15399–15410 | Cite as

Diverse roles of miR-335 in development and progression of cancers

  • Long-ji Luo
  • Dan-dan Wang
  • Jing Wang
  • Fan Yang
  • Jin-hai Tang


MicroRNAs (miRNAs), a series of small noncoding RNAs that regulate gene expression at the post-transcriptional/translational level, are pivotal in cell differentiation, biological development, occurrence, and development of diseases, especially in cancers. Early studies have shown that miRNA-335 (miR-335) is widely dysregulated in human cancers and play critical roles in tumorigenesis and tumor progression. In this review, we aim to summarize the regulation of miR-335 expression mechanisms in cancers. We focus on the target genes regulated by miR-335 and its downstream signaling pathways involved in the biological effects of tumor growth, invasion, and metastasis both in vitro and in vivo, and analyze the relationships between miR-335 expression and the clinical characteristics of tumors as well as its effects on prognosis. The collected evidences support the potential use of miR-335 in prognosis and diagnosis as well as the therapeutic prospects of miR-335 in cancers.


MicroRNA MiR-335 Cancers Biomarker 



This project is funded by National High Technology Research and Development Program of China (No. 2014AA020604), the National Natural Science Foundation of China (No. 81272470), the National key clinical specialist construction Programs of China (No. 2013[544]), Major Program of Natural Science Foundation of Jiangsu Province (No. BL2014090), and Natural Science Foundation of Jiangsu Province (No. BK20151579).

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Long-ji Luo
    • 1
    • 2
  • Dan-dan Wang
    • 2
    • 3
  • Jing Wang
    • 2
    • 3
  • Fan Yang
    • 1
    • 2
  • Jin-hai Tang
    • 2
  1. 1.Department of General SurgeryXuzhou Medical UniversityXuzhouChina
  2. 2.Department of General SurgeryJiangsu Cancer Hospital Affiliated to Nanjing Medical UniversityNanjingChina
  3. 3.Nanjing Medical UniversityNanjingChina

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