Tumor Biology

, Volume 37, Issue 11, pp 14513–14536 | Cite as

Natural products against cancer angiogenesis

  • El Bairi KhalidEmail author
  • EL-Meghawry EL-Kenawy Ayman
  • Heshu Rahman
  • Guaadaoui Abdelkarim
  • Agnieszka Najda


The process of angiogenesis is quite well-known nowadays. Some medicines and extracts affecting this process are already used routinely in supporting the conventional treatment of many diseases that are considered angiogenic such as cancer. However, we must be aware that the area of currently used drugs of this type is much narrower than the theoretical possibilities existing in therapeutic angiogenesis. Plant substances are a large and diverse group of compounds that are found naturally in fruits, vegetables, spices, and medicinal plants. They also have different anticancer properties. The aim of this literature review article is to present the current state of knowledge concerning the molecular targets of tumor angiogenesis and the active substances (polyphenols, alkaloids, phytohormones, carbohydrates, and terpenes) derived from natural sources, whose activity against cancer angiogenesis has been confirmed.


Natural products Angiogenesis Targets Chemoprevention Cancer 



Acidic fibroblast growth factor


Activator protein 1


Apoptosis-inducing factor


Ak strain thymoma








Apoptotic protease-activating factor


Activating transcription factor 4




Bcl-2-associated X protein


B cell lymphoma 2


Basic fibroblast growth factor


Chorioallantoic membrane


Cluster of differentiation 151


Cell division control protein 42 homolog


Cyclin-dependent kinase


Calf-intestinal alkaline phosphatase




Leukotriene-B(4) omega-hydroxylase 2


Direct IAP-binding protein with low pI


Delta-like ligand 4


Dimethyl xanthenyl acetic acid


Deoxyribonucleic acid


Prostaglandin E2


Endothelial cells


Epidermal growth factor


EGF-like domain-containing protein 7


Extracellular signal-regulated kinases


Fas ligand


Fibroblast growth factor


Granulocyte-macrophage colony-stimulating factor




Reactive oxygen species


Human epidermal receptor 2


Hepatocyte growth factor


Hypoxia-inducible factor




Janus kinase


c-Jun N-terminal kinases




Mitogen-activated protein


Monocyte chemoattractant protein 1


Magnetic resonance imaging


Mammalian target of rapamycin


Nuclear factor kappa-light-chain-enhancer of activated B cells




p21 activated kinase


Poly ADP ribose polymerase


Platelet-derived growth factor


Pigment epithelium-derived factor


PKR-like endoplasmic reticulum kinase




Phosphatidylinositol-glycan biosynthesis class F protein


Placental growth factor






Sodium-independent glutamate transporter


Glutamate-cysteine ligase catalytic subunit


Nuclear factor (erythroid-derived 2)-like 2


Second mitochondria-derived activator of caspases


Stimulator of interferon genes


Transforming growth factor-β


Tumor necrosis factor-α




Urokinase-type plasminogen activator


Vascular endothelial growth factor


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • El Bairi Khalid
    • 1
    Email author
  • EL-Meghawry EL-Kenawy Ayman
    • 2
    • 3
  • Heshu Rahman
    • 4
    • 5
  • Guaadaoui Abdelkarim
    • 6
  • Agnieszka Najda
    • 7
  1. 1.Independent Research Team in Cancer Biology and Bioactive Compounds, Faculty of Medicine and PharmacyUniversity Mohammed 1stOujdaMorocco
  2. 2.Department of Molecular Biology GEBRIUniversity of Sadat CitySadatEgypt
  3. 3.Pathology Department, College of MedicineTaif UniversityTaifSaudi Arabia
  4. 4.Department of Veterinary Clinical Diagnosis, Faculty of Veterinary MedicineUniversity Putra MalaysiaUPM SerdangMalaysia
  5. 5.Department of Medical Laboratory ScienceKomar University of Science and TechnologySulaimani CityIraq
  6. 6.Laboratory of Genetics and Biotechnology (LGB), Faculty of SciencesMohammed 1st University (UMP)OujdaMorocco
  7. 7.Quality Laboratory of Vegetable and Medicinal Materials, Department of Vegetable Crops and Medicinal PlantsUniversity of Life Sciences in LublinLublinPoland

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