Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients
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The aim of this study was to investigate the prognostic value of dicarbonyl/L-xylulose reductase (DCXR) in human hepatocellular carcinoma (HCC). Immunohistochemistry and tissue microarrays were used to evaluate DCXR protein expression levels. Image-Pro Plus was used to calculate the integral optic density (IOD) in each tissue sample, which represented the expression level of DCXR. DCXR proteins were found to be significantly lower in HCC tumor tissues (P < 0.0001) according to immunohistochemical analysis of DCXR protein levels in 74 paired HCC tissue and peritumoral non-cancer tissues. The prognostic value of DCXR in HCC was assessed in 290 cases of the training cohort and 74 cases of the validation cohort. Shorter overall survival (OS) time and shorter time to recurrence (TTR) in both the training and validation set were found to be associated with lower expression levels of DCXR. In the training set, the expression level of DCXR in HCC was an independent prognostic factor for OS according to univariate and multivariate analyses. In conclusion, DCXR expression is an independent prognostic factor for OS and TTR of post-operative HCC patients, and low expression levels of DCXR in HCC may indicate poor outcome of HCC patients after surgical resection.
KeywordsDicarbonyl/L-xylulose reductase Hepatocellular carcinoma Prognosis Tissue microarray
This study was supported by the National Science and Technology Major Project of China (No. 2012ZX10002007-001-005), and National Natural Science Foundation of China (Grant Nos. 81371829 and 31500141).
Compliance with ethical standards
All procedures were approved by the Human Research Ethics Committee at the Eastern Hepatobiliary Surgery Hospital and ChangZheng Hospital, and written informed consent was obtained from all patients before obtaining the tumor samples.
Conflicts of interest
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