HIC1 modulates uveal melanoma progression by activating lncRNA-numb
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Uveal melanoma (UM) is the most common primary intraocular cancer in adults. Although the diagnosis modality of primary UM was improved significantly, there are currently no effective therapies for metastatic UM. Hypermethylated in cancer 1 (HIC1) is frequently deleted or epigenetically silenced in various human cancers. However, the role and mechanism of HIC1 in UM is still unclear. In this study, we found that HIC1 acted as a tumor suppressor and that its expression was downregulated in UM. Functional studies demonstrated that ectopic expression of HIC1 in UM cells inhibited cell proliferation and invasion. Moreover, through long non-coding RNA (lncRNA) microarray and real-time PCR, we found that expression of lncRNA-numb was activated by HIC1 in UM. The results provide evidence that lncRNA-numb is a newly proposed tumor suppressor that is involved in HIC1-induced phenotypes. Taken together, our studies of UM reveal a critical role of HIC1 in the regulation of tumorigenesis, at least partly through its downstream target, lncRNA-numb, and provide a potential therapeutic target for UM.
KeywordsUveal melanoma HIC1 Long non-coding RNA Numb
Hypermethylated in cancer 1
Long non-coding RNA
This work was supported by The National Natural Science Foundation of China (31501035, 31470757) and The China Postdoctoral Science Foundation (2015M570370), the Scientific Research Program of The National Health and Family Planning Commission of China (201402014), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning (1410000159), the SMC-Chenxing Yong Scholar Program (2014, Class B), and the Science and Technology Commission of Shanghai (14JC1404100, 14JC1404200, 14430723100).
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