Tumor Biology

, Volume 37, Issue 8, pp 10851–10860 | Cite as

Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer

Original Article

Abstract

In spite of the fact that the great progress has been made in the treatment of non-small cell lung cancer (NSCLC), the prognosis of NSCLC remains comparatively dismal. Therefore, it is of great value to identify novel effective diagnostic biomarkers and therapeutic targets of NSCLC. Emerging evidence has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in cancer development. ENST00000434223 was recently identified as a lncRNA that is downregulated in early stage lung adenocarcinoma in a profiling study. However, little is known about its role in the development of NSCLC. In the present study, we found that ENST00000434223 was greatly downregulated in cancer tissues compared to adjacent normal tissues. ENST00000434223 overexpression suppressed the proliferation and migration in NSCLC cell lines in vitro. Moreover, ENST00000434223 overexpression reversed the epithelial-mesenchymal transition in NSCLC cell line. Our study suggests that ENST00000434223 may be a potential biomarker and a therapeutic target of NSCLC.

Keywords

Non-small cell lung cancer Long noncoding RNA ENST00000434223 Epithelial-mesenchymal-transition 

Notes

Compliance with ethical standards

Understanding and written consent of each subject were obtained. This study was approved by the Human Ethics Committee of Chest Hospital at JIAOTONG University (Shanghai, China).

The animal care and experimental protocols were approved by the institutional guidelines of Zhengzhou University.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  1. 1.School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina
  2. 2.Department of Pathologythe Affiliated Cancer Hospital to Zhengzhou UniversityZhengzhouChina
  3. 3.Department of Shanghai Lung Tumor Clinical Medical Centre, Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiChina
  4. 4.Department of Haematologythe Affiliated Cancer Hospital to Zhengzhou UniversityZhengzhouChina

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