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Tumor Biology

, Volume 37, Issue 8, pp 10805–10813 | Cite as

Computational prediction of Mycoplasma hominis proteins targeting in nucleus of host cell and their implication in prostate cancer etiology

  • Shahanavaj Khan
  • Mohammed Zakariah
  • Sellappan Palaniappan
Original Article

Abstract

Cancer has long been assumed to be a genetic disease. However, recent evidence supports the enigmatic connection of bacterial infection with the growth and development of various types of cancers. The cause and mechanism of the growth and development of prostate cancer due to Mycoplasma hominis remain unclear. Prostate cancer cells are infected and colonized by enteroinvasive M. hominis, which controls several factors that can affect prostate cancer growth in susceptible persons. We investigated M. hominis proteins targeting the nucleus of host cells and their implications in prostate cancer etiology. Many vital processes are controlled in the nucleus, where the proteins targeting M. hominis may have various potential implications. A total of 29/563 M. hominis proteins were predicted to target the nucleus of host cells. These include numerous proteins with the capability to alter normal growth activities. In conclusion, our results emphasize that various proteins of M. hominis targeted the nucleus of host cells and were involved in prostate cancer etiology through different mechanisms and strategies.

Keywords

Mycoplasma hominis Protein targeting In silico Host nucleus Prostate cancer Etiology 

Abbreviations

M. hominis

Mycoplasma hominis

ORFs

Open reading frames

NLS

Nuclear localization signal or sequence

BaCeILo

Balanced subcellular localization

LGT

Lateral gene transfer

Notes

Acknowledgments

The authors are thankful to the Deanship of the Scientific Research and Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Compliance with ethical standards

Conflicts of interest

None

Supplementary material

13277_2016_4970_MOESM1_ESM.doc (72 kb)
Table S1 (DOC 72 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Shahanavaj Khan
    • 1
    • 2
  • Mohammed Zakariah
    • 3
  • Sellappan Palaniappan
    • 4
  1. 1.Nanomedicine & Biotechnology Research Unit, Department of Pharmaceutics, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia
  2. 2.Department of BioscienceShri Ram Group of College (SRGC)MuzaffarnagarIndia
  3. 3.Research Center, College of Computer and Information ScienceKing Saud UniversityRiyadhSaudi Arabia
  4. 4.School of Science and EngineeringMalaysia University of Science and TechnologyPetaling JayaMalaysia

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