Tumor Biology

, Volume 37, Issue 8, pp 10533–10538 | Cite as

CLPTM1L polymorphism as a protective factor for lung cancer: a case–control study in southern Chinese population

  • Tianbo Jin
  • Bin Li
  • Na He
  • Yao Zhang
  • Ridong Xia
  • Longli Kang
  • Yipeng Ding
  • Dongya Yuan
Original Article


Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese Han population. We selected four SNPs in the CLPTM1L gene that were previously reported to be associated with lung cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to estimate the strength of the relationship between each CLPTM1L SNP and lung cancer risk. Allelic model analysis revealed that the minor alleles of all four SNPs were significantly associated with decreased lung cancer risk. Similar significant results were detected using genetic model analysis. In addition, we observed a protective effect of haplotype “TT” in the CLPTM1L gene. Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.


Lung cancer Single nucleotide polymorphisms (SNPs) CLPTM1L Case-control study 



This work is supported by National Natural Science Foundations (No. 81560516), Major science and technology research projects of Xizang (Tibet) Autonomous Region (2015), Natural Science Foundation of Xizang (Tibet) Autonomous Region (20152R-13-11), and the Major Training Program of Xizang Minzu University (No. 13myZP06).

Compliance with ethical standards

Conflict of interest

The authors declare no competing interests.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Tianbo Jin
    • 1
    • 2
    • 3
  • Bin Li
    • 4
  • Na He
    • 1
    • 2
    • 3
  • Yao Zhang
    • 1
    • 2
    • 3
  • Ridong Xia
    • 1
    • 2
    • 3
  • Longli Kang
    • 1
    • 2
    • 3
  • Yipeng Ding
    • 5
  • Dongya Yuan
    • 1
    • 2
    • 3
  1. 1.Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityXianyangChina
  2. 2.Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityXianyangChina
  3. 3.Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu UniversityXianyangChina
  4. 4.Department of OncologyFirst Affiliated Hospital, Xi’an Medical UniversityXi’anChina
  5. 5.Department of Emergency, People’s Hospital of Hainan ProvinceHaikouChina

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