CLPTM1L polymorphism as a protective factor for lung cancer: a case–control study in southern Chinese population
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Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese Han population. We selected four SNPs in the CLPTM1L gene that were previously reported to be associated with lung cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to estimate the strength of the relationship between each CLPTM1L SNP and lung cancer risk. Allelic model analysis revealed that the minor alleles of all four SNPs were significantly associated with decreased lung cancer risk. Similar significant results were detected using genetic model analysis. In addition, we observed a protective effect of haplotype “TT” in the CLPTM1L gene. Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.
KeywordsLung cancer Single nucleotide polymorphisms (SNPs) CLPTM1L Case-control study
This work is supported by National Natural Science Foundations (No. 81560516), Major science and technology research projects of Xizang (Tibet) Autonomous Region (2015), Natural Science Foundation of Xizang (Tibet) Autonomous Region (20152R-13-11), and the Major Training Program of Xizang Minzu University (No. 13myZP06).
Compliance with ethical standards
Conflict of interest
The authors declare no competing interests.
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