Metabolism alteration is one of the hallmarks of cancer cells. Although several studies have demonstrated that glycolysis played important roles in the progression of nasopharyngeal carcinoma (NPC), the functions of specific metabolism-associated genes remain largely unknown. In this study, it was found that Pyruvate dehydrogenase B (PDHB), which catalyzed the conversion of pyruvate to Acetyl-CoA, was downregulated in NPC cells. Forced expression of PDHB in NPC cells inhibited cell growth and migration, while knocking down the expression of PDHB promoted the growth, migration, and tumorigenesis of NPC cells. Mechanism study showed that PDHB inhibited ERK signaling and cell growth driven by RasV12. Collectively, our study demonstrated the suppressive roles of PDHB in the progression of NPC, and restoring the function of PDHB might be a promising strategy for NPC therapy.
PDHB NPC Ras Cell growth and migration
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This work was supported by the grants of Chen T. from the Medical Research Foundation of Guangdong Provincial Health and Family Planning Commission (A2015005), the National Natural Science Foundation of China (81402963), and the First Affiliated Hospital of Guangzhou Medical University (the “Young Elite Talents Program” and the “Science and Technology Support Projects”).
Compliance with ethical standards
All procedures performed in this study involving mouse were in accordance with the ethical standards of the hospital.
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