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Tumor Biology

, Volume 37, Issue 8, pp 10149–10153 | Cite as

RETRACTED ARTICLE: Evaluation of mRNA expression levels of IL-17A and IL-10 cytokines in cervical cancer

  • Setareh Akhavan
  • Aghdas Safari
  • Sima Azizmohammadi
  • Susan Azizmohammadi
  • Maysam Aslami
  • Emad Yahaghi
  • Mehri Seifoleslami
Original Article

Abstract

In this study, we evaluated mRNA expression levels of interleukin (IL)-10/IL-17A by quantitative real-time PCR and their clinical importance in cervical cancer. The IL-10 mRNA levels were higher in cervical cancer tissues as compared with corresponding normal tissues (p < 0.05). Moreover, IL-17A mRNA was significantly increased in cervical cancer tissues than in normal tissues (p < 0.05). Moreover, the high expression level of IL-10 mRNA was markedly related to International League of Gynecology and Obstetrics (FIGO) stage (p = 0.001), but no significant association was found with other clinical factors including age, tumor size, histological grades, and lymph node metastasis. Moreover, high expression levels of IL-17A were not associated with patients’ age, tumor size, FIGO stage, and histological grades while IL-17A expression was strongly linked to lymphatic metastasis (p = 0.001). These findings showed that IL-17A might have a crucial role in cervical cancer metastasis. Taken together, IL-17A expression was strongly linked to lymphatic metastasis, indicating that IL-17A might have a crucial role in cervical cancer metastasis. Moreover, our study suggested the association of IL-10 mRNA expression with clinical stage.

Keywords

Cervical IL-17A and IL-10 Metastasis Grade Histological 

Notes

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Setareh Akhavan
    • 1
  • Aghdas Safari
    • 2
  • Sima Azizmohammadi
    • 3
  • Susan Azizmohammadi
    • 3
  • Maysam Aslami
    • 4
  • Emad Yahaghi
    • 5
  • Mehri Seifoleslami
    • 6
  1. 1.Department of Obstetrics and Gynecology, School of Medicine, Imam Khomeini Hospital Complex and Vali Asr Hospital, Oncology WardTehran University of Medical SciencesTehranIran
  2. 2.Department of Gynecology, Imam Reza HospitalAJA University of Medical SciencesTehranIran
  3. 3.Department of Gynecology, Hajar HospitalAJA University of Medical SciencesTehranIran
  4. 4.Department of BiologyCalifornia State University StanislausCaliforniaUSA
  5. 5.Department of Molecular BiologyBaqiyatallah University of Medical SciencesTehranIran
  6. 6.Department of Gynecology, Khanevadeh HospitalAJA University of Medical SciencesTehranIran

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