Genetic variations in interleukin-6 polymorphism and the association with susceptibility and overall survival of osteosarcoma
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Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in both development and progression of many human malignancies. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms with susceptibility and overall survival of osteosarcoma in a Chinese population. A total of 412 subjects, including 206 patients with osteosarcoma and 206 healthy controls, were recruited and were assessed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) in this study. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-6 −174 G/C genotypes. Compared with the homozygote GG, the heterozygous GC genotype was associated with significantly increased risk for osteosarcoma (odds ratio [OR] = 1.58, 95 % confidence interval [CI] = 1.13–3.05, p = 0.028); the CC genotype was associated with increased risk for osteosarcoma (OR = 1.57, 95 % CI = 1.21–3.26, p = 0.022). Moreover, the genotype CC of IL-6 −174 G/C carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the GG genotype. The IL-6 −174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.
KeywordsIL-6 Osteosarcoma Single-nucleotide polymorphism Susceptibility
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