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Tumor Biology

, Volume 37, Issue 7, pp 9807–9811 | Cite as

Genetic variations in interleukin-6 polymorphism and the association with susceptibility and overall survival of osteosarcoma

  • Yunlong Qi
  • Chengbin Zhao
  • Hongxi Li
  • Benning Zhang
  • Kazuhiro Tada
  • Hiroyuki Abe
  • Midori Tada
Original Article

Abstract

Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in both development and progression of many human malignancies. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms with susceptibility and overall survival of osteosarcoma in a Chinese population. A total of 412 subjects, including 206 patients with osteosarcoma and 206 healthy controls, were recruited and were assessed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) in this study. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-6 −174 G/C genotypes. Compared with the homozygote GG, the heterozygous GC genotype was associated with significantly increased risk for osteosarcoma (odds ratio [OR] = 1.58, 95 % confidence interval [CI] = 1.13–3.05, p = 0.028); the CC genotype was associated with increased risk for osteosarcoma (OR = 1.57, 95 % CI = 1.21–3.26, p = 0.022). Moreover, the genotype CC of IL-6 −174 G/C carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the GG genotype. The IL-6 −174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.

Keywords

IL-6 Osteosarcoma Single-nucleotide polymorphism Susceptibility 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Yunlong Qi
    • 1
  • Chengbin Zhao
    • 1
  • Hongxi Li
    • 1
  • Benning Zhang
    • 2
  • Kazuhiro Tada
    • 2
  • Hiroyuki Abe
    • 3
  • Midori Tada
    • 4
  1. 1.Department of OrthopedicsThe Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Department of Immunology, The Institute of Medical OncologyHarbin Medical UniversityHarbinChina
  3. 3.Kudan Clinic, The Institute of Medical OncologyKudanJapan
  4. 4.Department of ImmunologyThe Institute of Medical OncologyKudanJapan

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