The potential role of CacyBP/SIP in tumorigenesis
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Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. This 30 kDa protein includes three domains and is involved in cell proliferation, differentiation, cytoskeletal rearrangement, and transcriptional regulation via binding to various proteins. Studies have also shown that the CacyBP/SIP is a critical protein in tumorigenesis. But, its promotion or suppression of cancer progression may depend on the cell type. In this review, the biological characteristics and target proteins of CacyBP/SIP have been described. Moreover, the exact role of CacyBP/SIP in various cancers is discussed.
KeywordsCacyBP/SIP β-Catenin Tumorigenesis Multidrug resistance
This work was supported by grants from the National Nature Science Foundation of China (Nos. 81272203, 2012K-13-01-08, and 30872964) and by Irma and Paul Milstein Program for Senior Health Awards.
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Conflicts of interest
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