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Tumor Biology

, Volume 37, Issue 7, pp 9951–9958 | Cite as

Elevated STMN1 promotes tumor growth and invasion in endometrial carcinoma

  • Xiaoying He
  • Yun Liao
  • Wen Lu
  • Gufeng Xu
  • Huan Tong
  • Jieqi Ke
  • Xiaoping Wan
Original Article

Abstract

Overexpression of stathmin (STMN1) is closely linked to tumor metastases and poor prognosis in endometrial carcinoma (EC). However, the underlying mechanism is little known. In the present study, we investigated the expression of STMN1 in EC. Subsequently, we assessed the role of STMN1 in EC cell proliferation and migration. Our data show that STMN1 is upregulated in EC, and elevated expression of STMN1 is correlated positively with tumor stage and lymph node metastasis. In vitro, forced expression of STMN1 promoted cell invasion and migration. In contrast, knockdown of STMN1 inhibited cell aggressive behaviors. Moreover, the expression and the activity changes of matrix metalloproteinases (MMP)-2/9 were observed in EC cells after the cells being silenced or overexpression of STMN1. In conclusion, STMN1 is an oncogene and it enhances the growth and invasion of EC possibly by mediating the secretion and activation of MMP2 and MMP9 protein.

Keywords

STMN1 Endometrial cancer MMP2 MMP9 Gelatin zymography 

Notes

Acknowledgments

Our study was supported by the National Natural Science Foundation of China (No. 81172476, No. 81272885, No. 81472427), the Science and Technology Commission of Shanghai Municipality (No. 13JC1404501), and the Doctoral Fund of Ministry of Education of China (No. 20120073110090).

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Xiaoying He
    • 1
  • Yun Liao
    • 2
  • Wen Lu
    • 3
  • Gufeng Xu
    • 2
  • Huan Tong
    • 4
  • Jieqi Ke
    • 4
  • Xiaoping Wan
    • 3
  1. 1.Department of Obstetrics and GynecologyShanghai Jiao Tong University Affiliated International Peace Maternity and Child Health HospitalShanghaiChina
  2. 2.Department of Obstetrics and Gynecology, Women’s Hospital, School of MedicineZhejiang UniversityHangzhouChina
  3. 3.Department of GynecologyTongji University School of Medicine Affiliated Shanghai First Maternity and Infant HospitalShanghaiChina
  4. 4.Department of Obstetrics and GynecologyShanghai Jiao Tong University Affiliated First People’s HospitalShanghaiChina

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