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Tumor Biology

, Volume 37, Issue 7, pp 9555–9563 | Cite as

The inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients among Chinese women, an indication for chemotherapy?

  • Yadong Sun
  • Xiaofeng Liu
  • Shude Cui
  • Lianfang Li
  • Peiqi Tian
  • Shanqing Liu
  • Yong Li
  • Mengmeng Yin
  • Chongjian Zhang
  • Qixin Mao
  • Jiaxiang Wang
Original Article
  • 130 Downloads

Abstract

Patients with Luminal A breast cancer often have favorable prognosis, but some of these patients still have lymph node metastases, it remains unclear what the role of adjuvant chemotherapy is in Luminal A subtype with lymph node metastases. The aim of this study was to find a new method to distinguish which Luminal A patient can be benefited from chemotherapy. We retrospectively investigated the inconsistency of molecular subtypes between primary foci and metastatic axillary lymph nodes in Luminal A breast cancer patients, and analyzed the clinicopathologic characteristics, Recurrence score (RS), disease-free survival (DFS), and overall survival (OS) in 146 Luminal A breast cancer patients. The discordance of molecular subtypes between primary foci and metastatic lymph nodes were explored by univariate and multivariate logistic regression. The DFS and OS were calculated by the Kaplan–Meier survival curves, and the Cox regression analyses were performed to identify independent prognostic factors for DFS and OS. In our results, the inconsistency was found in 55 patients (55/146, 37.67 %). Lymphatic vascular invasion (OR 6.402, 95 % CI 2.371–17.287, P < 0.001), lymph node stage (OR 2.147, 95 % CI 1.095–4.209, P = 0.026), and histological grade (OR 3.319, 95 % CI 1.101–8.951, P = 0.032) were significantly related to the inconsistency. The inconsistent group (non-Luminal A variations) had a poor prognosis compared with the consistent group, the DFS between the two groups was significantly different (P = 0.022), but the OS did not have obvious difference (P = 0.140). Moreover, the inconsistency was associated with high RS (P = 0.036). In conclusion, more aggressive molecular subtypes in metastatic lymph nodes, which associated with poor prognosis, were observed in Luminal A breast cancer patients, which indicate that chemotherapy is necessary for these patients.

Keywords

Breast cancer Luminal A Lymph node metastases Molecular subtype 

Abbreviations

RS

Recurrence score

DFS

Disease-free survival

OS

Overall survival

ER

Estrogen receptor

PR

Progesterone receptor

HER2/neu

Human epidermal growth factor receptor-2

FISH

Fluorescence in situ hybridization assay

IHC

Immunohistochemical

QRT-PCR

Quantitative reverse transcription polymerase chain reaction

TN

Triple negative

Notes

Acknowledgments

This work was supported by the fund of the “Research on Estrogen Receptor Heterogeneity of breast cancer” (project number: 142102410056) and Nanjing Youth Health Talented Person Fund (project number: QRX11111).

We thank Lianfang Li (Department of Breast, Affiliated Cancer Hospital of Zhengzhou University) for his expert technical assistance in indirect study.

Authors’ contributions

YDS carried out the clinical data analyses and prepared the manuscript.

XFL performed the statistical analyses and helped to prepare the manuscript.

JXW conceived of the study and gave administrative support for the manuscript.

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Yadong Sun
    • 1
    • 2
  • Xiaofeng Liu
    • 3
  • Shude Cui
    • 2
  • Lianfang Li
    • 2
  • Peiqi Tian
    • 2
  • Shanqing Liu
    • 2
  • Yong Li
    • 2
  • Mengmeng Yin
    • 2
  • Chongjian Zhang
    • 2
  • Qixin Mao
    • 2
  • Jiaxiang Wang
    • 1
  1. 1.Department of Surgery, the First Affiliated HospitalZhengzhou UniversityZhengzhouPeople’s Republic of China
  2. 2.Department of Breast, Henan Cancer HospitalAffiliated Cancer Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  3. 3.Department of breastNanjing Maternity and Child Health Hospital of Nanjing Medical UniversityNanjingPeople’s Republic of China

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