Tumor Biology

, Volume 37, Issue 4, pp 4293–4294 | Cite as

A premature proposal for new liver cancer seromarkers

  • Liu-Cheng Wu
  • Wen-Feng Gong
  • Jian-Hong Zhong

Optimal treatment of liver cancer depends on correctly determining whether tumors are primary hepatocellular carcinoma (HCC) or secondary carcinoma that metastasized from an extrahepatic source. Nearly all cancers that originate outside the liver can metastasize to that organ, raising the risk of misdiagnosis and suboptimal treatment. Indeed, the incidence of HCC in China is similar to that of metastatic liver carcinoma. While pathology provides the best method for differentiating primary and secondary cancer, it is rarely used preoperatively to diagnose liver cancer.

Instead, a combination of imaging and seromarker analysis, particularly of alpha-fetoprotein (AFP), is performed. Despite extensive studies analyzing the usefulness of AFP for diagnosing HCC [1], monitoring patients with cirrhosis for emergence of HCC [2] or detecting HCC recurrence after surgery [3, 4], its clinical value remains controversial. This is in part because sensitivity and specificity can vary widely,...


Liver Cancer Sialic Acid Leucine Aminopeptidase Liver Carcinoma Primary Hepatocellular Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by projects from the Self-raised Scientific Research Fund of the Ministry of Health of Guangxi Province (nos. Z2015716, Z2015601, Z2015621, Z2014241).

Conflicts of interests

The authors declare that they have no conflicts of interest concerning this article.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  1. 1.Gastroenterology DepartmentAffiliated Tumor Hospital of Guangxi Medical UniversityNanningChina
  2. 2.Hepatobiliary Surgery DepartmentAffiliated Tumor Hospital of Guangxi Medical UniversityNanningChina

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