A premature proposal for new liver cancer seromarkers
Optimal treatment of liver cancer depends on correctly determining whether tumors are primary hepatocellular carcinoma (HCC) or secondary carcinoma that metastasized from an extrahepatic source. Nearly all cancers that originate outside the liver can metastasize to that organ, raising the risk of misdiagnosis and suboptimal treatment. Indeed, the incidence of HCC in China is similar to that of metastatic liver carcinoma. While pathology provides the best method for differentiating primary and secondary cancer, it is rarely used preoperatively to diagnose liver cancer.
Instead, a combination of imaging and seromarker analysis, particularly of alpha-fetoprotein (AFP), is performed. Despite extensive studies analyzing the usefulness of AFP for diagnosing HCC , monitoring patients with cirrhosis for emergence of HCC  or detecting HCC recurrence after surgery [3, 4], its clinical value remains controversial. This is in part because sensitivity and specificity can vary widely,...
KeywordsLiver Cancer Sialic Acid Leucine Aminopeptidase Liver Carcinoma Primary Hepatocellular Carcinoma
This study was supported by projects from the Self-raised Scientific Research Fund of the Ministry of Health of Guangxi Province (nos. Z2015716, Z2015601, Z2015621, Z2014241).
Conflicts of interests
The authors declare that they have no conflicts of interest concerning this article.
- 5.Abdel-Hamid NM, Abouzied MM, Nazmy MH, Fawzy MA, Gerges AS. A suggested guiding panel of seromarkers for efficient discrimination between primary and secondary human hepatocarcinoma. Tumour Biol. 2015: [Epub ahead of print].Google Scholar
- 15.Jia Z, Wang L, Liu C, Yu Z, Chai L, Zhao M. Evaluation of alpha-fetoprotein-L3 and Golgi protein 73 detection in diagnosis of hepatocellular carcinoma. Contemp Oncol (Pozn). 2014;18(3):192–6.Google Scholar