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RETRACTED ARTICLE: Low p21 level is necessary for the suppressive effects of micoRNA-31 on glioma cell migration and invasion

  • Original Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

MicroRNAs (miRNAs), a kind of endogenous non-coding RNAs, regulate gene expression through binding to the 3′-untranslational region (UTR) of target messenger RNAs (mRNAs) and act as endogenous agents of RNA interference, resulting in either mRNA degradation or translational repression. MiR-31 has been demonstrated to be associated with the development and progression of glioma. However, the underlying molecular mechanism remains largely unclear. In the present study, we demonstrated that miR-31 only inhibited the cell migration and invasion, as well as the expression of a known miR-31 target oncogene radixin, in U251 glioma cells that expressed low level of p21; however, miR-31 showed no above effects on glioma SHG44 cells that highly expressed p21. Moreover, upregulation of p21 in U251 cells reversed the suppressive effects of miR-31 on the cell migration and invasion, suggesting that low p21 level is necessary for the miR-31-mediated inhibitory effects on glioma. Furthermore, analysis for 35 glioma specimens showed that the expression of radixin was negatively correlated with the miR-31 level in glioma tissues with low p21 expression; however, no such correlation was found in glioma tissues with high p21 level, further supporting that the low p21 level is necessary for the suppressive effect of miR-31 on the expression of its target oncogenes. In summary, our study demonstrates that the suppressive effect of miR-31 on glioma cell migration and invasion is p21-dependent, and suggests that miR-31 may be used for the treatment of patients with p21-deficent glioma.

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Authors and Affiliations

  1. The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong, 510282, China

    Jun Pan, Fengfei Lu, Hongchao Xu, Qifu Wang, Chunnan Lin & Shizhong Zhang

  2. Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Guangdong, 510282, China

    Jun Pan, Fengfei Lu, Hongchao Xu, Qifu Wang, Chunnan Lin & Shizhong Zhang

  3. Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, 253# Gongye Road, Guangzhou, 510282, Guangdong, China

    Jun Pan, Fengfei Lu, Hongchao Xu, Qifu Wang, Chunnan Lin & Shizhong Zhang

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  1. Jun Pan
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  2. Fengfei Lu
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Correspondence to Shizhong Zhang.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Pan, J., Lu, F., Xu, H. et al. RETRACTED ARTICLE: Low p21 level is necessary for the suppressive effects of micoRNA-31 on glioma cell migration and invasion. Tumor Biol. 37, 9663–9670 (2016). https://doi.org/10.1007/s13277-016-4788-5

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  • DOI: https://doi.org/10.1007/s13277-016-4788-5

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