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Tumor Biology

, Volume 37, Issue 7, pp 9139–9149 | Cite as

Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India

  • Soumee Ghosh
  • Sudakshina Ghosh
  • Biswabandhu Bankura
  • Makhan Lal Saha
  • Suvendu Maji
  • Souvik Ghatak
  • Arup Kumar Pattanayak
  • Susanta Sadhukhan
  • Manalee Guha
  • Senthil Kumar Nachimuthu
  • Chinmay Kumar Panda
  • Biswanath Maity
  • Madhusudan Das
Original Article

Abstract

Gastric cancer is one of the most common malignancies in India. DNA repair gene or xenobiotic pathway gene polymorphisms have recently been shown to affect individual susceptibility to gastric cancer. Here, the possible interaction between common polymorphisms in X-ray repair cross complementing group I (XRCC1) gene and glutathione S-transferase (GST) genes (GSTM1, GSTT1 and GSTP1), smoking and alcohol consumption and overall survival in gastric cancer patients were evaluated. In this population-based case control study, 70 gastric cancer patients and 82 healthy controls were enrolled. The epidemiological data were collected by a standard questionnaire, and blood samples were collected from each individual. XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms were determined by polymerase chain reaction and direct DNA sequencing. GSTM1 and GSTT1 null polymorphisms and GSTP1 Ile105Val polymorphism were identified by multiplex polymerase chain reaction and restriction fragment length polymorphism (RFLP), respectively. The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07–5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84–40.55). An elevated risk for GC was observed in smokers and alcohol consumers carrying GSTP1 Ile/Val +Val/Val genotype (p = 0.041; odds ratio = 3.71; 95 % CI 0.98–14.12; p = 0.002; odds ratio = 12.31; 95 % CI 1.71–88.59). These findings suggest that XRCC1 rs25487 and GSTP1 rs1695 can be considered as a risk factor associated with gastric cancer and might be used as a molecular marker for evaluating the susceptibility of the disease.

Keywords

Gastric cancer XRCC1 GSTP1 SNPs 

Notes

Acknowledgments

The work was supported by the Department of Biotechnology, Government of India [BT/360/NE/TBP/2012 DATE-25.03.2013, sanctioned to Prof. Madhusudan Das]

Compliance with ethical standards

Conflicts of interest

None

Supplementary material

13277_2015_4780_MOESM1_ESM.docx (13 kb)
Supplementary Table 1 (DOCX 12 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Soumee Ghosh
    • 1
  • Sudakshina Ghosh
    • 1
  • Biswabandhu Bankura
    • 1
  • Makhan Lal Saha
    • 3
  • Suvendu Maji
    • 3
  • Souvik Ghatak
    • 2
  • Arup Kumar Pattanayak
    • 1
  • Susanta Sadhukhan
    • 1
  • Manalee Guha
    • 1
  • Senthil Kumar Nachimuthu
    • 2
  • Chinmay Kumar Panda
    • 4
  • Biswanath Maity
    • 1
  • Madhusudan Das
    • 1
  1. 1.Department of ZoologyUniversity of CalcuttaKolkataIndia
  2. 2.Department of BiotechnologyMizoram UniversityAizawlIndia
  3. 3.Department of SurgeryInstitute of Post Graduate Medical Education & ResearchKolkataIndia
  4. 4.Department of Oncogene Regulation and Viral Associated Human CancerChittaranjan Cancer Research InstituteKolkataIndia

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