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Tumor Biology

, Volume 37, Issue 7, pp 8979–8983 | Cite as

Circulating serum levels of angiopoietin-1 and angiopoietin-2 in nasopharynx and larynx carcinoma patients

  • Murat Emin Güveli
  • Derya Duranyildiz
  • Ahmet Karadeniz
  • Elif Bilgin
  • Murat Serilmez
  • Hilal Oguz Soydinc
  • Vildan Yasasever
Original Article
  • 118 Downloads

Abstract

We aimed to determine the serum levels of angiogenic factors, namely angiopoietins, in nasopharyngeal and laryngeal carcinoma patients. We also aimed to seek the relation of these molecules with tumor grade and their utility as diagnostic biomarkers. We evaluated angiopoietin 1 and 2 levels innasopharynx and larynx cancer patients before treatment. Angiopoietin 2 levels were significantly elevated in larynx carcinoma patients and tended to be elevated in nasopharynx cancer patients compared with healthy controls. However, angiopoietin 1 levels were similar in cancer patients and controls. Angiopoietin 1 levels were significantly higher in nasopharyngeal cancer patients with advanced stages compared to earlier stages. On the other hand, angiopoietin 2 levels were similar in advanced and earlier stage cancer patients.

Keywords

Angiopoietins Nasopharynx cancer Larynx cancer 

Notes

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Murat Emin Güveli
    • 1
  • Derya Duranyildiz
    • 1
  • Ahmet Karadeniz
    • 1
  • Elif Bilgin
    • 1
  • Murat Serilmez
    • 1
  • Hilal Oguz Soydinc
    • 1
  • Vildan Yasasever
    • 1
  1. 1.Istanbul University Oncology InstituteIstanbulTurkey

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