Tumor Biology

, Volume 37, Issue 7, pp 9657–9661 | Cite as

Clinical significance of GRHL3 expression in diffuse large B cell lymphoma

  • Wei Liu
  • Minwen Ha
  • Xiaodong Wang
  • Nanchang Yin
Original Article


In the present study, we assessed the GRHL3 expression in 967 patients with diffuse large B cell lymphomas to identify the potential prognostic value and the development of specific therapeutic strategies. All patients enrolled were from a previous study by Hao Zhang et al. (BMC Cancer 14:333, 2014). GRHL3 expression status was evaluated by immunohistochemical analysis. Survival analysis using the Kaplan–Meier method and multivariate analysis were conducted to adjust the effect of GRHL3 expression as a potential independent prognostic factor. In the enrolled 967 patients, GRHL3 expression was detected in 398 (41.16 %) patients under immunohistochemical analysis. The 5-year survival rate in patients with GRHL3 expression was significantly lower than that in those without GRHL3 expression (37.8 vs 52.8 %, P < 0.001). Multivariate analysis identified GRHL3 expression as an independent predictor of poor survival. The sensitivity and specificity of GRHL3 for the diagnosis of germinal center B cell (GCB)/non-GCB was 89.2 % (182/204) and 82.1 % (174/212), respectively. GRHL3 expression may be useful as a prognostic factor and for the diagnosis GCB/non-GCB of diffuse large B cell lymphoma.


Diffuse large B cell lymphomas Survival GRHL3 



Bone marrow


Complete remission


Diffuse large B cell lymphoma


Human leukocyte antigen


Phosphate-buffered saline


Germinal center B cell



We would like to express our gratitude to Hao Zhang et al. for their help of clinical pathology records and statistical analysis.

Authors’ contributions

WL and NY carried out the experiment and drafted the manuscript. MH participated in the design of the study and performed the statistical analysis. XW conceived the study, participated in its design and coordination, and helped to draft the manuscript. All the authors read and approved the final manuscript.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Wei Liu
    • 1
  • Minwen Ha
    • 1
  • Xiaodong Wang
    • 2
  • Nanchang Yin
    • 2
  1. 1.Department of Medical OncologyThe First Affiliated Hospital of Liaoning Medical UniversityJinzhouChina
  2. 2.Department of Thoracic SurgeryThe First Affiliated Hospital of Liaoning Medical UniversityJinzhouChina

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