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Tumor Biology

, Volume 37, Issue 3, pp 2823–2831 | Cite as

E2F1: a promising regulator in ovarian carcinoma

  • Lei Zhan
  • Yu Zhang
  • Wenyan Wang
  • Enxue Song
  • Yijun Fan
  • Bing Wei
Review

Abstract

E2F is a family of transcription factors that recognized to regulate the expression of genes essential for a wide range of cellular functions, including cell cycle progression, DNA repair, DNA replication, differentiation, proliferation, and apoptosis. E2F1, the most classic member of the E2F family, exhibits a complex role in tumor development regulation. In recent years, a growing body of data suggested an intimate relationship between E2F1 and ovarian carcinoma. And E2F1 was well identified to play dual functions and serve as a useful prognostic indicator in ovarian carcinoma. However, the mechanism underlying E2F1 associated with ovarian carcinoma remains elusive. It is necessary to clarify the fundamental role of E2F1 in ovarian carcinoma. In this review, we tried to sum up the knowledge of E2F1, including its structure and related mechanism. We also attempt to absorb the research achievements and collect the mechanism of E2F1 in ovarian carcinoma.

Keywords

E2F1 Ovarian carcinoma Regulator Cellular functions Overlapping 

Abbreviations

ARHI

Ras homologue member I

BTB

3-Butoxy-1,8,9-trihydroxy-6Hbenzofuro[3,2-c]benzopyran-6-one

CDKs

Cyclin-dependent kinases

DBD

DNA-binding domain

DP

Dimerization partner

EOC

Epithelial ovarian cancer

ER

Estrogen receptor

GCT

Germ cell tumors

HPMCs

Human peritoneal mesothelial cell

IGS

Invasiveness gene signatures

pRb

Retinoblastoma protein

HDAC

Histone deacetylase

LZ

Leuzine zipper

MB

Marked box

miRs

MicroRNAs

NLS

Nuclear localization signals

NSAIDs

Non-steroidal anti-inflammatory

OCSCs

Ovarian cancer stem cells

PTEN

Phosphatase and tensin homologue

SBTs

Serous borderline tumors

SCAs

Ovarian serous carcinomas

SCA3s

High-grade SCAs

Notes

Acknowledgments

None

Compliance with ethical standard

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Lei Zhan
    • 1
  • Yu Zhang
    • 1
  • Wenyan Wang
    • 1
  • Enxue Song
    • 1
  • Yijun Fan
    • 1
  • Bing Wei
    • 1
  1. 1.Department of Gynecology and ObstetricsThe Second Affiliated Hospital of Anhui Medical UniversityHefeiChina

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