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Increased expression of SOX4 is associated with colorectal cancer progression

Tumor Biology volume 37, pages 9131–9137 (2016)Cite this article

Abstract

Sex-determining region Y-related high-mobility group box 4 (SOX4) has been proven to serve as a critical role in cancer progression. However, the pathological role of SOX4 in colorectal cancer (CRC) remains unknown. The aim of this study was to investigate the role of SOX4 in CRC. In this study, we investigated the expression of SOX4 in CRC tissues by immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blot. We also evaluated the effect of SOX4 on cell proliferation and invasion by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and transwell assay. The SOX4 messenger RNA (mRNA) and protein expression were markedly higher in CRC tissues compared with adjacent normal mucosa tissues. Inhibition of SOX4 could suppress CRC cell proliferation, and invasion in vitro. Our findings indicate that targeting SOX4 might provide a new therapeutic modality for the treatment of CRC patients.

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Acknowledgments

This study was supported by the National Natural Science Foundation of Hainan (no. 814309)

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Affiliations

  1. Department of General Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, China

    Baochun Wang, Yixiong Li & Fengbo Tan

  2. Department of General Surgery, Hainan Province People’s Hospital, Haikou, 570311, China

    Baochun Wang & Zhanxiang Xiao

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  1. Baochun Wang
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  2. Yixiong Li
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  3. Fengbo Tan
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Correspondence to Yixiong Li.

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Wang, B., Li, Y., Tan, F. et al. Increased expression of SOX4 is associated with colorectal cancer progression. Tumor Biol. 37, 9131–9137 (2016). https://doi.org/10.1007/s13277-015-4756-5

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  • DOI: https://doi.org/10.1007/s13277-015-4756-5

Keywords

  • Colorectal cancer
  • SOX4
  • Proliferation
  • Invasion
  • EMT
  • Targeted therapy