Tumor Biology

, Volume 37, Issue 7, pp 9131–9137 | Cite as

Increased expression of SOX4 is associated with colorectal cancer progression

  • Baochun Wang
  • Yixiong Li
  • Fengbo Tan
  • Zhanxiang Xiao
Original Article


Sex-determining region Y-related high-mobility group box 4 (SOX4) has been proven to serve as a critical role in cancer progression. However, the pathological role of SOX4 in colorectal cancer (CRC) remains unknown. The aim of this study was to investigate the role of SOX4 in CRC. In this study, we investigated the expression of SOX4 in CRC tissues by immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blot. We also evaluated the effect of SOX4 on cell proliferation and invasion by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and transwell assay. The SOX4 messenger RNA (mRNA) and protein expression were markedly higher in CRC tissues compared with adjacent normal mucosa tissues. Inhibition of SOX4 could suppress CRC cell proliferation, and invasion in vitro. Our findings indicate that targeting SOX4 might provide a new therapeutic modality for the treatment of CRC patients.


Colorectal cancer SOX4 Proliferation Invasion EMT Targeted therapy 



This study was supported by the National Natural Science Foundation of Hainan (no. 814309)

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Baochun Wang
    • 1
    • 2
  • Yixiong Li
    • 1
  • Fengbo Tan
    • 1
  • Zhanxiang Xiao
    • 2
  1. 1.Department of General Surgery, Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Department of General Surgery, Hainan Province People’s HospitalHaikouChina

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