Tumor Biology

, Volume 37, Issue 7, pp 9071–9076 | Cite as

Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity

Original Article


Protein arginine methylation, which is mediated by the protein arginine methyltransferases (PRMTs), is associated with numerous fundamental cellular processes. Our previous studies have shown that PRMT1 activated Hedgehog signaling in the esophageal squamous cell carcinoma (ESCC) cells and promoted the growth and migration of cancer cells. However, the detailed mechanisms are unknown. In this study, it was found that PRMT1 interacted with the transcriptional factor Gli1 (glioma-associated oncogene homolog 1) in ESCC cells. The DNA-binding domain (DBD) of Gli1 is responsible for its interaction with PRMT1. Moreover, PRMT1 promoted the methylation of Gli1, and knocking down the expression of PRMT1 impaired the transcriptional activity as well as the biological functions of Gli1. Taken together, our study demonstrated that PRMT1 is a positive regulator of Hedgehog signaling, and PRMT1 might be a therapeutic target for ESCC.


PRMT1 Gli1 Methylation ESCC 


Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  1. 1.Department of Cardiothoracic Surgery, Changhai HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of Medical OncologyChangzheng Hospital, Second Military Medical UniversityShanghaiChina

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