miR-492G>C polymorphism (rs2289030) is associated with overall survival of hepatocellular carcinoma patients
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Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) are considered potential markers of cancer risk and prognosis in various cancers. In the current study, the primary aim is to determine whether the miR-492G>C polymorphism (rs2289030) altered hepatocellular carcinoma (HCC) prognosis. The SNP rs2289030 of miR-492 was genotyped using DNA from blood samples of 362 HCC patients that had undergone surgical resection of a HCC tumor. The associations between overall survival and demographic characteristics, clinical features, and the SNP rs2289030 were estimated using the Cox proportional hazards model. Results showed that patients who carried the CG genotype (P = 0.015, hazard ratio [HR] = 0.704, 95 % confidence interval [CI] 0.530–0.934) and CG+GG genotype (P = 0.011, HR = 0.703, 95 % CI 0.536–0.924) had significantly decreased risk of death compared to those with the CC genotype. Similar results were found in the multivariate analysis adjusted by tumor size and venous invasion. Further stratification analysis indicated that the effect of rs2289030 had more prominence in patients ≤50 years old and that reported ever using alcohol, male gender, a family history of HCC, being HbsAg or alpha fetoprotein (AFP) positive, differentiation I + II, presence of venous invasion or cirrhosis, multiple tumors, and pTNM stage I + II. Results from this study illustrate the potential use of miR-492 rs2289030 as a prognostic marker for HCC patients that have undergone a surgical resection of the tumor.
KeywordsHepatocellular carcinoma Survival miRNA Genetic polymorphisms
We thank all the patients who agreed to participate in this study. The study is supported by the National Natural Science Foundation of China (31100895 and 81472618 [to D.-K.J.]), Outstanding Young Scholar Project of Fudan University (to D.-K.J.), and an intramural research grant for new young teachers from Fudan University (to D.-K.J.), an intramural research grant for promotion of the scientific research ability of young teachers from Fudan University (to D.-K.J.), an intramural research grant from Huashan Hospital, Fudan University (to J.X.), an intramural research grant from Fudan-VARI Center for Genetic Epidemiology, Fudan University (to J.X.)., the Research Fund of the State Key Laboratory of Genetic Engineering, Fudan University (to L.Y. and J.X.), and the Ellrodt-Schweighauser Family Chair of Cancer Genomic Research of NorthShore University HealthSystem (J. X.).
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