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Tumor Biology

, Volume 37, Issue 3, pp 2789–2804 | Cite as

Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling

  • Balraj Singh Gill
  • Prateek Sharma
  • Raj Kumar
  • Sanjeev Kumar
Review

Abstract

A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity.

Keywords

Ganoderma lucidum Terpenoids Polysaccharides Ganoderic acid (GA) Cancer 

Notes

Acknowledgments

BSG, PS, RK and SK thank Central University of Punjab, Bathinda, for providing the necessary facilities to carry out the present work. The authors acknowledge and thank Dr. Alpana Saini for assistance in editing the article.

Compliance with ethical standards

Conflicts of interests

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Balraj Singh Gill
    • 1
  • Prateek Sharma
    • 1
  • Raj Kumar
    • 2
  • Sanjeev Kumar
    • 1
    • 2
  1. 1.Centre for BiosciencesCentral University of PunjabBathindaIndia
  2. 2.Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied SciencesCentral University of PunjabBathindaIndia

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