Tumor Biology

, Volume 37, Issue 2, pp 1559–1565 | Cite as

Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells

  • Masoumeh Es-haghi
  • Sara Soltanian
  • Hesam DehghaniEmail author


Directed cell migration is a crucial mobility phase of cancer stem cells having stemness and tumorigenic characteristics. It is known that CXCR4 plays key roles in the perception of chemotactic gradients throughout the directed migration of CSCs. There are a number of complex signaling pathways and transcription factors that coordinate with CXCR4/CXCL12 axis during directed migration. In this review, we focus on some transcription factors such as Nanog, NF-κB, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells.


Cancer stem cell CXCR4/CXCL12 axis Nanog NF-κB Directed cell migration Metastasis Stemness 



The research work in the laboratory of H.D. is supported by grant number 3/25064 from Ferdowsi University of Mashhad, Mashhad, Iran, and grant number 100311 from Council for Stem Cell Sciences and Technologies of Iran and the Research Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Masoumeh Es-haghi
    • 1
  • Sara Soltanian
    • 2
  • Hesam Dehghani
    • 1
    • 3
    Email author
  1. 1.Division of Biotechnology, Faculty of Veterinary MedicineFerdowsi University of MashhadMashhadIran
  2. 2.Department of Biology, Faculty of ScienceShahid Bahonar University of KermanKermanIran
  3. 3.Embryonic and Stem Cell Biology and Biotechnology Research Group, Institute of BiotechnologyFerdowsi University of MashhadMashhadIran

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