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Tumor Biology

, Volume 37, Issue 2, pp 1521–1525 | Cite as

Determination of malignant potential of cervical intraepithelial neoplasia

Review

Abstract

Basic diagnostic procedures in cervical cancer screening are able to set the diagnosis but they do not provide any information about the biological nature and behavior of lesions. The causal link of HPV infection and cervical cancer and discoveries of complex interactions between host and HPV genome opened new possibilities in molecular diagnostics. HPV DNA analysis, determination of viral load, detection of E6 and E7 mRNA transcripts, identifying of methylation profiles, genomic changes, miRNAs, and telomerase activity should be the right choice for exact diagnostics and prediction of behavior of premalignant lesions of the cervix. These findings set a completely new light not only in diagnostic but also in management and treatment of cervical dysplasia and cervical cancer.

Keywords

Cervical intraepithelial neoplasia Cervical cancer HPV 

Notes

Acknowledgments

This work was supported by the project “Molecular diagnostics of cervical cancer” (ITMS: 26220220113); Project “Increasing opportunities for career growth in research and development in the field of medical sciences;” ITMS 26110230067, Comenius University Grants 303/2011, 242/2012, and 287/2015; and the VEGA Grant 1/0271/12 as well as the APVV-0224-12 Grant.

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • E. Kudela
    • 1
  • V. Holubekova
    • 2
  • A. Farkasova
    • 3
  • J. Danko
    • 1
  1. 1.Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine in MartinComenius UniversityBratislavaSlovak Republic
  2. 2.Biomedical Center Martin, Jessenius Faculty of Medicine in MartinComenius University BratislavaSlovak Republic
  3. 3.Institute of Pathological Anatomy, Jessenius Faculty of Medicine in MartinComenius UniversityBratislavaSlovak Republic

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