Tumor Biology

, Volume 37, Issue 8, pp 10229–10234 | Cite as

Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer

Original Article


Published studies showed controversial findings about the relationship between glutathione S-transferase M1 (GSTM1) null genotype and clinical outcomes of patients with colorectal cancer. We performed a meta-analysis to quantitatively assess the association between GSTM1 null genotype and prognosis of patients with colorectal cancer. We systematically searched Pubmed, Embase, and Web of Science to identify prospective or retrospective cohort studies assessing the association of GSTM1 null genotype with overall survival (OS) or disease-free survival (DFS) in colorectal cancer. The hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) were used to assess the association of GSTM1 null genotype with OS or DFS. Finally, 15 studies from 14 publications with 4326 colorectal cancer patients were included into the meta-analysis. There was no heterogeneity in the meta-analysis relating OS (I 2 = 0 %) and DFS (I 2 = 0 %). Overall, GSTM1 null genotype was significantly associated with poor OS in patients with colorectal cancer (HR = 1.18, 95 % CI 1.07–1.30, P = 0.001). In addition, GSTM1 null genotype was also significantly associated with poor DFS in patients with colorectal cancer (HR = 1.15, 95 % CI 1.03–1.28, P = 0.015). No obvious risk of publication bias was observed. GSTM1 null genotype is significantly associated with poor OS and DFS in patients with colorectal cancer, which suggests that GSTM1 null genotype confers poor effect on the prognosis of colorectal cancer.


Colorectal cancer Glutathione S-transferase M1 Prognosis 



This work was supported by the National Natural Science Foundation (81430062). This work was also supported in part by the program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU and the Priority Academic Program of Jiangsu Higher Education Institutions.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Shushan Yan
    • 1
    • 2
    • 3
  • Zengfang Wang
    • 4
  • Zengyan Wang
    • 5
  • Quanhong Duan
    • 2
  • Xiaochen Wang
    • 1
  • Jun Li
    • 6
    • 1
  • Beicheng Sun
    • 1
  1. 1.Liver Transplantation Center of the First Affiliated HospitalNanjing Medical UniversityNanjingChina
  2. 2.Department of Surgical OncologyThe Eighty-First Hospital of People’s Liberation ArmyNanjingChina
  3. 3.Department of Anorectal Surgerythe Affiliated Hospital of Weifang Medical UniversityWeifangChina
  4. 4.Department of Gynaecology and ObstetricsMaternal and Children Health’s HospitalWeifangChina
  5. 5.Operating Room of People’s Hospital of ZhuchengZhuchengChina
  6. 6.Department of General Surgerythe Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina

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