Tumor Biology

, Volume 37, Issue 6, pp 7239–7244 | Cite as

Association of HER2 codon 655 polymorphism with ovarian cancer

  • Rafał Watrowski
  • Dan Cacsire Castillo-Tong
  • Eva Schuster
  • Michael B. Fischer
  • Paul Speiser
  • Robert Zeillinger
Original Article


The role of the human epidermal growth factor receptor 2 (HER2) codon 655 (Ile655Val) polymorphism in ovarian cancer is not fully understood. Two studies indicated a possible association between the Val allele and elevated risk or reduced prognosis of ovarian cancer. We investigated the HER2 codon 655 (rs1136201) polymorphism in 242 Austrian women—142 ovarian cancer patients and 100 healthy controls—by polymerase chain reaction and pyrosequencing. Associations between Ile655Val polymorphism and clinicopathological variables (e.g., age, FIGO stage, grading, serous vs. non-serous histology) were evaluated. The genotype distributions in ovarian cancer patients and controls were: AA; 66.2 %, AG; 25.35 %, GG; 8.45 %, and AA; 63 %, AG; 34 %, GG; 3.7 %, respectively (OR 1.15, CI 95 % 0.67–1.96). We observed a non-significant trend toward elevated cancer risk in Val/Val genotype (OR 2.98, CI 95 % 0.82–10.87, p = 0.10). Of note, 11 out of 12 Val/Val homozygotes were postmenopausal. The link between the Val/Val homozygosity and age over 50 years at diagnosis (OR 0.15, CI 95 % 0.02–1.2) was barely significant (p = 0.056). Summarizing, our data indicated a non-significant trend toward increased ovarian cancer risk in the Val/Val homozygosity, especially in women aged above 50 years. Further large-cohort studies focusing on the role of the HER2 codon 655 Val allele are needed.


HER2 Codon 655 HER2 Ile655Val Ovarian cancer Polymorphism 



RW was supported by the Ernst Mach Grant of the Austrian Exchange Service (ÖAD) financed by the Austrian Ministry of Education, Science and Culture (BMBWK).

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Rafał Watrowski
    • 1
    • 2
  • Dan Cacsire Castillo-Tong
    • 2
  • Eva Schuster
    • 2
  • Michael B. Fischer
    • 3
  • Paul Speiser
    • 2
  • Robert Zeillinger
    • 2
  1. 1.Department of Gynecology and Obstetrics, St. JosefskrankenhausTeaching Hospital of the University of FreiburgFreiburgGermany
  2. 2.Department of Obstetrics and Gynecology, Molecular Oncology GroupMedical University of ViennaViennaAustria
  3. 3.Department of Blood Group Serology and Transfusion MedicineMedical University of ViennaViennaAustria

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