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Tumor Biology

, Volume 37, Issue 7, pp 8579–8585 | Cite as

FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells

  • Lei Cui
  • Shengchun Dang
  • Jianguo Qu
  • Zhengfa Mao
  • Xuqing Wang
  • Jianxin Zhang
  • Jixiang Chen
Original Article

Abstract

The transcriptional factor Forkhead box protein C2 (FOXC2) was recently demonstrated to be up-regulated in various cancer types. However, its expression profile and the biological functions in pancreatic cancer remain unknown. In this study, we examined the expression pattern of FOXC2 in pancreatic ductal adenocarcinoma (PDAC) tissues and investigated the functions of FOXC2 in the progression of PDAC. It was found that the expression of FOXC2 was up-regulated in PDAC samples. Forced expression of FOXC2 promoted the growth and migration of the PDAC cells, while knocking down the expression of FOXC2 inhibited the growth and migration of the PDAC cells. Moreover, FOXC2 was found to interact with beta-catenin and promote cell growth by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of FOXC2 in PDAC, and FOXC2 might be a therapeutic target for PDAC.

Keywords

PDAC FOXC2 Beta-catenin/TCF signaling Cell growth and migration 

Notes

Compliance with ethical standards

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Lei Cui
    • 1
  • Shengchun Dang
    • 1
  • Jianguo Qu
    • 1
  • Zhengfa Mao
    • 1
  • Xuqing Wang
    • 1
  • Jianxin Zhang
    • 1
  • Jixiang Chen
    • 1
  1. 1.General Surgery Department, Affiliated HospitalJiangsu UniversityZhenjiangPeople’s Republic of China

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