Tumor Biology

, Volume 37, Issue 2, pp 1487–1492 | Cite as

Circulating epigenetic biomarkers in melanoma

  • Yu Xin
  • Zheng Li
  • Matthew T.V. Chan
  • William Ka Kei Wu


Recent researches have shed new light on the importance of epigenetic alterations, including promoter hypermethylation and microRNA dysregulation, in the initiation and progression of melanoma. The clinical utilization of circulating epigenetic markers in melanoma has also been investigated. In this review, we explored the literature and summarized the latest progress in the discovery of circulating epigenetic markers, namely methylated DNA and microRNAs, for non-invasive diagnosis of melanoma, as well as their measurability and predictability. We also discussed the utility of these epigenetic markers as novel prognostic and predictive markers and their association with melanoma clinical phenotypes, including recurrence and patients’ survival. Large-cohort validations are warranted to maximize the clinical utilization of these markers.


Melanoma Epigenetic Circulating biomarkers miRNA 



This work was supported by grants from the National Natural Science Foundation of China (NSFC) (Grant Number: 81401847).


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yu Xin
    • 1
  • Zheng Li
    • 2
  • Matthew T.V. Chan
    • 3
  • William Ka Kei Wu
    • 3
    • 4
  1. 1.Department of Dermatology, Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina
  2. 2.Department of Orthopedics Surgery, Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina
  3. 3.Department of Anaesthesia and Intensive CareThe Chinese University of Hong KongHong KongChina
  4. 4.State Key Laboratory of Digestive Disease, LKS Institute of Health SciencesThe Chinese University of Hong KongHong KongChina

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