Note of the methodological flaws in the paper entitled “Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis”
With great interest, we read the paper “Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis” (by Chen PQ et al.) , which has reached important conclusions about the relationship between polymorphisms in interleukin (IL)-4/IL-13 pathway genes and glioma risk. Through quantitative analysis, the meta-analysis found no association between IL-4/IL-13 pathway genetic polymorphisms and glioma risk (Chen et al. in Tumor Biol 36:121–127, 2015). The meta-analysis is the most comprehensive study of polymorphisms in the IL-4/IL-13 pathway and glioma risk. Nevertheless, some deficiencies still exist in this meta-analysis that we would like to raise.
KeywordsIL-4/IL-13 Glioma Polymorphisms Meta-analysis
Compliance with ethical standards
Conflicts of interest