Tumor Biology

, Volume 37, Issue 6, pp 8337–8347 | Cite as

Genetic variants in EBV reactivation-related genes and the risk and survival of breast cancer

  • Wei Zhang
  • Zheng-Zheng Zhang
  • Lu-Ying Tang
  • Ying Lin
  • Feng-Xi Su
  • Xiao-Ming Xie
  • Xue-Fen Su
  • Ze-Fang Ren
Original Article


Tumor susceptibility gene 101 (TSG101) and activating transcription factor 2 (ATF2) have been suggested to involve in the reactivation of EBV which has implications in the development and progression of breast cancer. Therefore, the polymorphisms of TSG101 and ATF2 may associate with breast cancer risk and prognosis. A case-control study with 1551 breast cancer cases and 1605 age-matched controls were conducted in Guangzhou, China. We have also successfully followed up 1168 cases until December 31, 2014. The variant allele of TSG101 rs2292179 was associated with a non-significant reduced risk of breast cancer, particularly among women with BMI < 24 (kg/m2) (P for interaction <0.05). For ATF2 rs3845744, the variant allele was also associated with a significantly reduced breast cancer risk [odds ratio (OR) (95 % confidence interval (CI)) 0.86 (0.74∼1.00)], and the association occurred among only postmenopausal women [OR (95 % CI) 0.69 (0.54∼0.88)] (P for interaction <0.05). Breast cancer risk was further reduced with the increasing numbers of the variant G alleles of the two polymorphisms (P for trend <0.05). We did not find an overall association of the two loci with breast cancer prognosis, while the hazard ratios of the two loci (AG/GG vs. AA) were significantly higher among postmenopausal women than premenopausal women (P = 0.046, 0.016 for TSG101 rs2292179 and ATF2 rs3845744, respectively). In summary, the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m2) and postmenopausal women, respectively. The two SNPs and menopausal status may have a significant interaction on breast cancer progression.


TSG101 ATF2 Polymorphisms Prognosis Breast cancer 



This work was supported by the National Natural Science Foundation of China (grant number: 81273147). The authors would like to thank all the study participants and nursing and administrative staff in the Breast Departments of The First and Second Affiliated Hospitals and Cancer Center, Sun Yat-sen University.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Wei Zhang
    • 1
  • Zheng-Zheng Zhang
    • 1
    • 2
  • Lu-Ying Tang
    • 3
  • Ying Lin
    • 4
  • Feng-Xi Su
    • 5
  • Xiao-Ming Xie
    • 6
  • Xue-Fen Su
    • 7
  • Ze-Fang Ren
    • 1
    • 8
  1. 1.The School of Public Health, Sun Yat-sen UniversityGuangzhouChina
  2. 2.Aviation Hygiene Management DivisionChina Southern Airlines Company LimitedGuangzhouChina
  3. 3.The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  4. 4.The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  5. 5.The Second Affiliated HospitalSun Yat-sen UniversityGuangzhouChina
  6. 6.The Sun Yat-Sen University Cancer CenterGuangzhouChina
  7. 7.School of Public Health and Primary Care, Faculty of MedicineThe Chinese University of Hong KongHong KongChina
  8. 8.Department of Statistics and Epidemiology, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, School of Public HealthSun Yat-sen UniversityGuangzhouChina

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