Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression
- 213 Downloads
Basaloid squamous cell carcinoma (BSCC), a variant of squamous cell carcinoma (SCC), is a rare and aggressive epithelial malignancy which has been reported in only 0.1–11 % of primary esophageal carcinomas. In this study, a comparison of clinicopathological features and protein expression between esophageal BSCC (EBSCC) and conventional esophageal SCC (ESCC) cases from Brazil was performed in order to find factors that can be relevant to better characterize EBSCC. The expression of HER2, epidermal growth factor receptor (EGFR), Ki-67, and cyclins (A, B1, and D1) in 111 cases (95 ESCC and 16 EBSCC) was evaluated by immunohistochemistry using tissue microarray. When the clinicopathological data were compared, no significant difference was found between the two histological types. Although the difference is not significant (p = 0.055), the EGFR expression was more frequent in the conventional ESCC than in the EBSCC group. Our results indicate that the clinicopathological profiles of conventional ESCC and EBSCC are similar and provide no indicators for differences in prognosis between these two groups.
KeywordsBasaloid squamous cell carcinoma EGFR HER2 Cyclins Ki-67
The authors thank Carlos Ferreira Nascimento and Severino Ferreira da Silva for providing technical assistance. This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP).
Compliance with ethical standards
This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP 2010/19572-6).
Conflicts of interest
- 1.Fujita H, Kakegawa T, Yamana H, Shima I, Toh Y, Tomita Y, et al. Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer. Comparison of three-field lymphadenectomy with two-field lymphadenectomy. Ann Surg. 1995;222:654–62.CrossRefPubMedPubMedCentralGoogle Scholar
- 18.Huang Z, Shen Y, Liang Y, Wu X. Basaloid squamous cell carcinoma of the esophagus: an immunohistochemical study of 8 cases. Chin Med J (Engl). 2001;114:1084–8.Google Scholar