Tumor Biology

, Volume 37, Issue 2, pp 1437–1444 | Cite as

The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers

  • Chenhui Ma
  • Xuefei Shi
  • Qingqing Zhu
  • Qian Li
  • Yafang Liu
  • Yanwen Yao
  • Yong Song


Long noncoding RNAs (lncRNAs), which refer to a group of RNAs with length more than 200 nucleotides and limited protein-coding potential, play a widespread role in regulating biological processes, such as cell differentiation, proliferation, apoptosis, and migration. LncRNAs are dysregulated in multiple cancers, playing an either oncogenic or tumor-suppressive role. LncRNA GAS5 is a recently identified tumor suppressor involved in several cancers, like breast cancer, prostate cancer, lung cancer, and colorectal cancer. The low-expression pattern confers tumor cells elevated capacity of proliferation and predicts poorer prognosis. Existing studies mirror that lncRNA GAS5 promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. In this review, we will summarize the current knowledge about this vital lncRNA, from its discovery, characteristics, and biological function to molecular mechanism in various neoplasms.


Long noncoding RNAs GAS5 Cancer Tumor suppressor Proliferation Apoptosis 



Growth arrest-specific transcript 5


Long noncoding RNAs




Small nucleolar RNA


Mammalian target of rapamycin


Nonsense-mediated decay


Glucocorticoid receptor


Glucocorticoid response element


DNA-binding domain


Plexin C1


Y-box binding protein 1


Androgen deprivation therapy


Castrate-resistant prostate cancer


Nonsmall-cell lung cancer




Epidermal growth factor receptor tyrosine kinase inhibitors


Insulin-like growth factor 1 receptor


Malignant pleural mesothelioma


Cyclin-dependent kinase 6


Renal cell carcinoma


Hox transcript antisense intergenic RNA


Polycomb repressive complex 2


Lysine-specific demethylase 1



This work was supported by grants from the Natural Science Foundation of Jiangsu Province (no. BK2011658), Clinical Science and Technology Project of Jiangsu Province (no. BL2013026), and the National Natural Science Foundation of China (no. 81401903). We apologize to all researchers whose relevant contributions were not cited due to space limitations.

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Chenhui Ma
    • 1
  • Xuefei Shi
    • 3
  • Qingqing Zhu
    • 1
  • Qian Li
    • 1
  • Yafang Liu
    • 2
  • Yanwen Yao
    • 1
  • Yong Song
    • 1
  1. 1.Department of Respiratory Medicine, Jinling HospitalMedical School of Nanjing UniversityNanjingChina
  2. 2.Department of Respiratory Medicine, Jinling HospitalSouthern Medical University (Guangzhou)NanjingChina
  3. 3.Department of Respiratory MedicineHuzhou Central HospitalHuzhouChina

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