Tumor Biology

, Volume 37, Issue 2, pp 1407–1410 | Cite as

Serum microRNAs as potential noninvasive biomarkers for glioma

  • Xin Yu
  • Zheng Li


Gliomas are derived from astroglial precursors or astrocytes, accounting for 40 % central nervous system tumors. MicroRNAs (miRNAs) are a class of endogenous, small (19- to 23-nucleotides) non-coding RNAs involved in cancer progression. Recent studies show that circulating miRNAs are associated with the clinicopathological features and prognosis of gliomas. Serum miRNAs may serve as novel biomarkers for gliomas diagnosis. This review explores the possibilities of using serum miRNAs as prognostic, diagnostic markers, and therapeutic targets in gliomas.


MicroRNA Gliomas Circulating miRNAs Serum miRNAs Biomarkers 



This work was supported by grants from the National Natural Science Foundation of China (NSFC) (grant number: 81401847).

Compliance with ethical standards

Conflicts of interest



  1. 1.
    Zadran S, Remacle F, Levine R. Surprisal analysis of glioblastoma multiform (gbm) microRNA dynamics unveils tumor specific phenotype. PLoS One. 2014;9:e108171.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Gerin C, Pallud J, Grammaticos B, Mandonnet E, Deroulers C, Varlet P, et al. Improving the time-machine: estimating date of birth of grade ii gliomas. Cell Prolif. 2012;45:76–90.CrossRefPubMedGoogle Scholar
  3. 3.
    Badoual M, Gerin C, Deroulers C, Grammaticos B, Llitjos JF, Oppenheim C, et al. Oedema-based model for diffuse low-grade gliomas: application to clinical cases under radiotherapy. Cell Prolif. 2014;47:369–80.CrossRefPubMedGoogle Scholar
  4. 4.
    Kreth S, Thon N, Kreth FW. Epigenetics in human gliomas. Cancer Lett. 2014;342:185–92.CrossRefPubMedGoogle Scholar
  5. 5.
    Low SY, Ho YK, Too HP, Yap CT, Ng WH. MicroRNA as potential modulators in chemoresistant high-grade gliomas. J Clin Neurosci. 2014;21:395–400.CrossRefPubMedGoogle Scholar
  6. 6.
    Tao T, Wang Y, Luo H, Yao L, Wang L, Wang J, et al. Involvement of fos-mediated mir-181b/mir-21 signalling in the progression of malignant gliomas. Eur J Cancer. 2013;49:3055–63.CrossRefPubMedGoogle Scholar
  7. 7.
    Bralten LB, Nouwens S, Kockx C, Erdem L, Hoogenraad CC, Kros JM, et al. Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas. PLoS One. 2011;6:e22000.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Dong H, Luo L, Hong S, Siu H, Xiao Y, Jin L, et al. Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. BMC Syst Biol. 2010;4:163.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Novakova J, Slaby O, Vyzula R, Michalek J. MicroRNA involvement in glioblastoma pathogenesis. Biochem Biophys Res Commun. 2009;386:1–5.CrossRefPubMedGoogle Scholar
  10. 10.
    Rafiee MR, Malekzadeh Shafaroudi A, Rohban S, Khayatzadeh H, Kalhor HR, Mowla SJ. Enrichment of a rare subpopulation of mir-302-expressing glioma cells by serum deprivation. Cell J. 2015;16:494–505.PubMedPubMedCentralGoogle Scholar
  11. 11.
    Wang J, Yi X, Tang H, Han H, Wu M, Zhou F. Direct quantification of microRNA at low picomolar level in sera of glioma patients using a competitive hybridization followed by amplified voltammetric detection. Anal Chem. 2012;84:6400–6.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Fareh M, Turchi L, Virolle V, Debruyne D, Almairac F, de-la-Forest Divonne S, et al. The mir 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through cxcr4 repression and consequent disruption of the shh-gli-nanog network. Cell Death Differ. 2012;19:232–44.CrossRefPubMedGoogle Scholar
  13. 13.
    Masui K, Cloughesy TF, Mischel PS. Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol. 2012;38:271–91.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Li Z, Yu X, Shen J, Chan MT, Wu WK. MicroRNA in intervertebral disc degeneration. Cell Prolif. 2015;48(3):278–83.CrossRefPubMedGoogle Scholar
  15. 15.
    Li Z, Yu X, Shen J, Wu WK, Chan MT. MicroRNA expression and its clinical implications in ewing’s sarcoma. Cell Prolif. 2015;48:1–6.CrossRefPubMedGoogle Scholar
  16. 16.
    Yu X, Li Z, Liu J. MiRNAs in primary cutaneous lymphomas. Cell Prolif. 2015;48(3):271–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Yu X, Li Z, Shen J, Wu WK, Liang J, Weng X, et al. MicroRNA-10b promotes nucleus pulposus cell proliferation through rhoc-akt pathway by targeting hoxd10 in intervetebral disc degeneration. PLoS One. 2013;8:e83080.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Li Z, Lei H, Luo M, Wang Y, Dong L, Ma Y, et al. DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer. 2015;18:43–54.CrossRefPubMedGoogle Scholar
  19. 19.
    Yu X, Li Z. MicroRNAs regulate vascular smooth muscle cell functions in atherosclerosis (review). Int J Mol Med. 2014;34:923–33.PubMedGoogle Scholar
  20. 20.
    Li Z, Yu X, Shen J, Jiang Y. MicroRNA dysregulation in uveal melanoma: a new player enters the game. Oncotarget. 2015;6(7):4562–8.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Li Z, Yu X, Wang Y, Shen J, Wu WK, Liang J, et al. By downregulating tiam1 expression, microRNA-329 suppresses gastric cancer invasion and growth. Oncotarget. 2015;6:17559–69.Google Scholar
  22. 22.
    Ge W, Yu DC, Li QG, Chen X, Zhang CY, Ding YT. Expression of serum mir-16, let-7f, and mir-21 in patients with hepatocellular carcinoma and their clinical significances. Clin Lab. 2014;60:427–34.CrossRefPubMedGoogle Scholar
  23. 23.
    Gui J, Tian Y, Wen X, Zhang W, Zhang P, Gao J, et al. Serum microRNA characterization identifies mir-885-5p as a potential marker for detecting liver pathologies. Clin Sci (Lond). 2011;120:183–93.CrossRefGoogle Scholar
  24. 24.
    Li L, Guo Z, Wang J, Mao Y, Gao Q. Serum mir-18a: a potential marker for hepatitis b virus-related hepatocellular carcinoma screening. Dig Dis Sci. 2012;57:2910–6.CrossRefPubMedGoogle Scholar
  25. 25.
    Guo F, Tian J, Lin Y, Jin Y, Wang L, Cui M. Serum microRNA-92 expression in patients with ovarian epithelial carcinoma. J Int Med Res. 2013;41:1456–61.CrossRefPubMedGoogle Scholar
  26. 26.
    Shi W, Du J, Qi Y, Liang G, Wang T, Li S, et al. Aberrant expression of serum miRNAs in schizophrenia. J Psychiatr Res. 2012;46:198–204.CrossRefPubMedGoogle Scholar
  27. 27.
    Redova M, Poprach A, Nekvindova J, Iliev R, Radova L, Lakomy R, et al. Circulating mir-378 and mir-451 in serum are potential biomarkers for renal cell carcinoma. J Transl Med. 2012;10:55.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Rotkrua P, Shimada S, Mogushi K, Akiyama Y, Tanaka H, Yuasa Y. Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. Br J Cancer. 2013;108:932–40.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Tan Y, Ge G, Pan T, Wen D, Chen L, Yu X, et al. A serum microRNA panel as potential biomarkers for hepatocellular carcinoma related with hepatitis b virus. PLoS One. 2014;9:e107986.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Wu C, Cao Y, He Z, He J, Hu C, Duan H, et al. Serum levels of mir-19b and mir-146a as prognostic biomarkers for non-small cell lung cancer. Tohoku J Exp Med. 2014;232:85–95.CrossRefPubMedGoogle Scholar
  31. 31.
    Scheffer AR, Holdenrieder S, Kristiansen G, von Ruecker A, Muller SC, Ellinger J. Circulating microRNAs in serum: Novel biomarkers for patients with bladder cancer? World J Urol 2014;32:353–8.Google Scholar
  32. 32.
    Liu GH, Zhou ZG, Chen R, Wang MJ, Zhou B, Li Y, et al. Serum mir-21 and mir-92a as biomarkers in the diagnosis and prognosis of colorectal cancer. Tumour Biol. 2013;34:2175–81.CrossRefPubMedGoogle Scholar
  33. 33.
    Geekiyanage H, Jicha GA, Nelson PT, Chan C. Blood serum miRNA: non-invasive biomarkers for Alzheimer’s disease. Exp Neurol. 2012;235:491–6.CrossRefPubMedGoogle Scholar
  34. 34.
    Yang C, Wang C, Chen X, Chen S, Zhang Y, Zhi F, et al. Identification of seven serum micrornas from a genome-wide serum microrna expression profile as potential noninvasive biomarkers for malignant astrocytomas. Int J Cancer. 2013;132:116–27.CrossRefPubMedGoogle Scholar
  35. 35.
    Dong L, Li Y, Han C, Wang X, She L, Zhang H. miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. Int J Oncol. 2014;45:746–56.PubMedGoogle Scholar
  36. 36.
    Manterola L, Guruceaga E, Gallego Perez-Larraya J, Gonzalez-Huarriz M, Jauregui P, Tejada S, et al. A small noncoding rna signature found in exosomes of gbm patient serum as a diagnostic tool. Neuro-Oncology. 2014;16:520–7.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Wu J, Li L, Jiang C. Identification and evaluation of serum microRNA-29 family for glioma screening. Mol Neurobiol. 2015;52:1540–6.Google Scholar
  38. 38.
    Wei X, Chen D, Lv T, Li G, Qu S. Serum microRNA-125b as a potential biomarker for glioma diagnosis. Molecular neurobiology 2014. [Epub ahead of print]Google Scholar
  39. 39.
    Lai NS, Wu DG, Fang XG, Lin YC, Chen SS, Li ZB, et al. Serum microRNA-210 as a potential noninvasive biomarker for the diagnosis and prognosis of glioma. Br J Cancer. 2015;112(Suppl):1241–6.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Sun J, Liao K, Wu X, Huang J, Zhang S, Lu X. Serum microRNA-128 as a biomarker for diagnosis of glioma. Int J Clin Exp Med. 2015;8:456–63.PubMedPubMedCentralGoogle Scholar
  41. 41.
    Yue X, Lan F, Hu M, Pan Q, Wang Q, Wang J. Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. J Neurosurg 2015:1-7. [Epub ahead of print]Google Scholar
  42. 42.
    Wang J, Zhang KY, Liu SM, Sen S. Tumor-associated circulating microRNAs as biomarkers of cancer. Molecules. 2014;19:1912–38.CrossRefPubMedGoogle Scholar
  43. 43.
    Zavesky L, Jandakova E, Turyna R, Langmeierova L, Weinberger V, Minar L, et al. New perspectives in diagnosis of gynaecological cancers: emerging role of circulating microRNAs as novel biomarkers. Neoplasma. 2015;62(4):509–20.CrossRefPubMedGoogle Scholar
  44. 44.
    Allegra A, Alonci A, Campo S, Penna G, Petrungaro A, Gerace D, et al. Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int J Oncol. 2012;41:1897–912.PubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of DermatologyPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of Orthopaedic SurgeryPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Personalised recommendations