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Tumor Biology

, Volume 37, Issue 2, pp 1445–1450 | Cite as

The roles of microRNAs in Wilms’ tumors

  • Xin Yu
  • Zheng Li
  • Matthew T V Chan
  • William Ka Kei Wu
Review

Abstract

Wilms’ tumor is the most common renal tumor in children in which diffusely anaplastic or unfavorable histology foreshadows poor prognosis. MicroRNAs are small, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating evidence shows that microRNA dysregulation takes part in the pathogenesis of many renal diseases, such as chronic kidney diseases, polycystic kidney disease, renal fibrosis, and renal cancers. In Wilms’ tumor, dysregulation of some key oncogenic or tumor-suppressing microRNAs, such as miR-17~92 cluster, miR-185, miR-204, and miR-483, has been documented. In this review, we will summarize current evidence on the role of dysregulated microRNAs in the development of Wilms’ tumor.

Keywords

Wilms’ tumor Nephroblastoma MicroRNAs 

Notes

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Xin Yu
    • 1
  • Zheng Li
    • 2
  • Matthew T V Chan
    • 3
  • William Ka Kei Wu
    • 3
    • 4
  1. 1.Department of DermatologyPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of Orthopaedic SurgeryPeking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina
  3. 3.Department of Anaesthesia and Intensive CareThe Chinese University of Hong KongHong KongChina
  4. 4.State Key Laboratory of Digestive Disease, LKS Institute of Health SciencesThe Chinese University of Hong KongHong KongChina

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