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Tumor Biology

, Volume 37, Issue 5, pp 6875–6879 | Cite as

Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population

  • Jian Shi
  • Meng Yuan
  • Shuang Liu
  • Xiaoyang Duan
  • Juan Chen
Original Article

Abstract

Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in the development of cervical cancer. A hospital-based case–control study was conducted in 380 patients with cervical cancer and 380 healthy controls to investigate the possible associations of IL-27 gene polymorphisms (−964A/G, 2905T/G, and 4730T/C), with susceptibility to cervical cancer and clinical outcome. Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60–0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72–0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65–0.94). However, the genotype and allele frequencies of IL-27 (−964A/G and 4730T/C) polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Our results showed that the IL-27 2905T/G genotypes were associated with decreased susceptibility and development of cervical cancer in Chinese Han population.

Keywords

IL-27 Cervical cancer Single nucleotide polymorphism Susceptibility 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jian Shi
    • 1
  • Meng Yuan
    • 2
  • Shuang Liu
    • 3
  • Xiaoyang Duan
    • 1
  • Juan Chen
    • 4
  1. 1.Department of Medical OncologyFourth Hospital of Hebei Medical UniversityShijiazhuangChina
  2. 2.College of Science and TechnologyYichangChina
  3. 3.Department of PathologyBethune International Peace HospitalShijiazhuangChina
  4. 4.Xingtai National HospitalXingtaiChina

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