Tumor Biology

, Volume 37, Issue 5, pp 6875–6879 | Cite as

Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population

  • Jian Shi
  • Meng Yuan
  • Shuang Liu
  • Xiaoyang Duan
  • Juan Chen
Original Article


Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in the development of cervical cancer. A hospital-based case–control study was conducted in 380 patients with cervical cancer and 380 healthy controls to investigate the possible associations of IL-27 gene polymorphisms (−964A/G, 2905T/G, and 4730T/C), with susceptibility to cervical cancer and clinical outcome. Our results suggested that the IL-27 2905T/G was significantly associated with a decreased risk of cervical cancer (TG vs. TT, odds ratio (OR) = 0.77; 95 % confidence interval (CI) = 0.60–0.86; GG vs. TT, OR = 0.95; 95 % CI = 0.72–0.96; TG+GG vs. TT, OR = 0.87; 95 % CI = 0.65–0.94). However, the genotype and allele frequencies of IL-27 (−964A/G and 4730T/C) polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Our results showed that the IL-27 2905T/G genotypes were associated with decreased susceptibility and development of cervical cancer in Chinese Han population.


IL-27 Cervical cancer Single nucleotide polymorphism Susceptibility 


  1. 1.
    Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.CrossRefPubMedGoogle Scholar
  2. 2.
    Liu D, Zhou P, Zhang L, et al. Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A. Tumour Biol. 2011;32:941–50.CrossRefPubMedGoogle Scholar
  3. 3.
    Ibeanu OA. Molecular pathogenesis of cervical cancer. Cancer Biol Ther. 2011;11:295–306.CrossRefPubMedGoogle Scholar
  4. 4.
    Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet. 2007;370:890–907.CrossRefPubMedGoogle Scholar
  5. 5.
    Katki HA, Kinney WK, Fetterman B, Lorey T, Poitras NE, Cheung L, et al. Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice. Lancet Oncol. 2011;12:663–72.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Barbisan G, Perez LO, Contreras A, Golijow CD. TNF-α and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk. Tumour Biol. 2012;33:1549–56.CrossRefPubMedGoogle Scholar
  7. 7.
    Chae SC, Li CS, Kim KM, Yang JY, Zhang Q, et al. Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population. J Hum Genet. 2007;52:355–61.CrossRefPubMedGoogle Scholar
  8. 8.
    Li CS, Zhang Q, Lee KJ, Cho SW, Lee KM, et al. Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population. J Gastroenterol Hepatol. 2009;24:1692–6.CrossRefPubMedGoogle Scholar
  9. 9.
    Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005;5:521–31.CrossRefPubMedGoogle Scholar
  10. 10.
    Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 2003;19:641–4.CrossRefPubMedGoogle Scholar
  11. 11.
    Huang ZQ, Wang JL, Pan GG, Wei YS. Association of single nucleotide polymorphisms in IL-12 and IL-27 genes with colorectal cancer risk. Clin Biochem. 2012;45:54–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Wei YS, Lan Y, Luo B, Lu D, Nong HB. Association of variants in the interleukin-27 and interleukin-12 gene with nasopharyngeal carcinoma. Mol Carcinog. 2009;48:751–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Tao YP, Wang WL, Li SY, Zhang J, Shi QZ, et al. Associations between polymorphisms in IL-12A, IL-12B, IL-12Rbeta, 1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer. J Cancer Res Clin Oncol. 2012;138:1891–900.CrossRefPubMedGoogle Scholar
  14. 14.
    Zhang S, Wang Y, Wang M, Ji Z. IL-27 -964A>G polymorphism and the risk of breast cancer: a case-control study. Tumour Biol. 2014;35:12099–102.CrossRefPubMedGoogle Scholar
  15. 15.
    Peng Q, Qin X, He Y, Chen Z, Deng Y, et al. Association of IL27 gene polymorphisms and HBV-related hepatocellular carcinoma risk in a Chinese population. Infect Genet Evol. 2013;16:1–4.CrossRefPubMedGoogle Scholar
  16. 16.
    Owaki T, Asakawa M, Fukai F, et al. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J Immunol. 2006;177:7579–87.CrossRefPubMedGoogle Scholar
  17. 17.
    Miyazaki Y, Inoue H, Matsumura M, et al. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-deficient mice. J Immunol. 2005;175:2401–7.CrossRefPubMedGoogle Scholar
  18. 18.
    Yoshimoto T, Morishima N, Mizoguchi I, Shimizu M, Nagai H, et al. Antiproliferative activity of IL-27 on melanoma. J Immunol. 2008;180:6527–35.CrossRefPubMedGoogle Scholar
  19. 19.
    Ho MY, Leu SJ, Sun GH, Tao MH, Tang SJ, et al. IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities. J Immunol. 2009;183:6217–26.CrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jian Shi
    • 1
  • Meng Yuan
    • 2
  • Shuang Liu
    • 3
  • Xiaoyang Duan
    • 1
  • Juan Chen
    • 4
  1. 1.Department of Medical OncologyFourth Hospital of Hebei Medical UniversityShijiazhuangChina
  2. 2.College of Science and TechnologyYichangChina
  3. 3.Department of PathologyBethune International Peace HospitalShijiazhuangChina
  4. 4.Xingtai National HospitalXingtaiChina

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